1195110-34-9

Basic information

• Product Name: 4,4'-(5,5-difluoro-1,9-diphenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinine-3,7-diyl)diphenol
• Synonyms: 4,4'-(5,5-difluoro-1,9-diphenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinine-3,7-diyl)diphenol
• CAS NO: 1195110-34-9
• Molecular Weight: 529.353
• Mol File: 1195110-34-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 4,4'-(5,5-difluoro-1,9-diphenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinine-3,7-diyl)diphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-(5,5-difluoro-1,9-diphenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinine-3,7-diyl)diphenol(1195110-34-9)
• EPA Substance Registry System: 4,4'-(5,5-difluoro-1,9-diphenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinine-3,7-diyl)diphenol(1195110-34-9)

Safety Data

• Hazardous Substances Data: 1195110-34-9(Hazardous Substances Data)

Upstream product

• 52-90-4 L-Cysteine 
• 1093881-86-7 1-(4-hydroxyphenyl)-4-nitro-3-phenylbutan-1-one 
• 7637-07-2 boron trifluoride 
• 99-93-4 4-Hydroxyacetophenone 
• 100-52-7 benzaldehyde 
• 2657-25-2 4'-hydroxychalcone 
• 1194952-47-0 [5-(4-hydroxyphenyl)-3-phenyl-1H-pyrrol-2-yl]-[5-(4-hydroxyphenyl)-3-phenylpyrrol-2-ylidene]-amine 
• 109-63-7 boron trifluoride diethyl etherate 

Downstream Products

• 1195110-33-8 4-(4-phenyl-5-(3-phenyl-5-(4-prop-2-ynyloxyphenyl)pyrrol-2-ylideneamino)-1H-pyrrol-2-yl)phenol, BF₂ chelate 
• 1195110-35-0 C₃₈H₂₆BF₂N₃O₂ 
• 1217599-63-7 N(C₆H₅C₄HNC₆H₄O(CH₂)3SO₃)2BF₂^(2-) 
• 1195110-37-2 4-[4-(4-{5-[5-(4-hydroxyphenyl)-3-phenyl-1H-pyrrol-2-ylimino]-4-phenyl-5H-pyrrol-2-yl}phenoxymethyl)-[1,2,3]triazol-1-yl]butyric acid , BF₂ chelate 
• 1195110-38-3 {2-[4-(4-{5-[5-(4-hydroxyphenyl)-3-phenyl-7H-pyrrol-2-ylimino]-4-phenyl-5H-pyrrol-2-yl}-phenoxymethyl)-[l,2,3]triazol-l-yl]ethyl}carbamic acid t-butyl ester, BF₂ chelate 
• 1448244-87-8 C₄₀H₃₂BF₂N₃O₅S₂ 

Relevant articles and documents

A convenient method for multicolour labelling of proteins with BODIPY fluorophores via tyrosine residues

Fluorescence is an essential imaging modality for labelling and visualising cells and sub-cellular structures. Multicolour labelling is especially challenging due to differences in physicochemical and photophysical behaviour of structurally unrelated fluorophores in the heterogeneous environments found in sub-cellular compartments. Herein, we report the conjugation of three azide-bearing BODIPYs with similar core structures but widely different emission wavelengths (green, red and NIR) to tyrosine residues of a model globular protein (BSA) via a common linking methodology. The resulting BODIPY-BSA conjugates have demonstrated multi-wavelength fluorescence emission for biological applications. Fluorescence imaging was performed in HeLa cells through live cell confocal microscopy imaging, with good intracellular location visualisation observed.

Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restrictionviafluorescence imaging

Dietary restriction (DR), as a natural intervention, not only benefits the neuroendocrine system, but also has an antiaging action. Acetylcholinesterase (AChE) is one of the most important bioactive substances and plays a major part in choline changes in the aging process. Thus, we aim to evaluate the effect of DR on AChE in the brains of aging animals. In this study, we synthesize a NIR fluorescent probe BD-AChE for the real-time andin situmonitoring of AChE level changes in living cells and living mice, notably in brains.In situvisualization with BD-AChE verified a decrease in the AchE level in the brains of mice aging models. Evidently, the prepared probe has the excellent capability of measuring AChE variation in the brains of aging mice with DRviaNIR fluorescence bioimaging, indicating that long-term DR can effectively affect AChE levels in the brain. The attenuation of AChE level in the brain of aging mice after DR could be helpful in infering the advantageous impact of DR on age-related neurodegenerative disease, as a better treatment alternative in the future.

Near-Infrared Fluorescent Probe Activated by Nitroreductase for in Vitro and in Vivo Hypoxic Tumor Detection

Tumor hypoxia is correlated with increased resistance to chemotherapy and poor overall prognoses across a number of cancer types. We present here a cancer cell-selective and hypoxia-responsive probe (fol-BODIPY) designed on the basis of density functional theory (DFT)-optimized quantum chemical calculations. The fol-BODIPY probe was found to provide a rapid fluorescence "off-on"response to hypoxia relative to controls, which lack the folate or nitro-benzyl moieties. In vitro confocal microscopy and flow cytometry analyses, as well as in vivo near-infrared optical imaging of CT26 solid tumor-bearing mice, provided support for the contention that fol-BODIPY is more readily accepted by folate receptor-positive CT26 cancer cells and provides a superior fluorescence "off-on"signal under hypoxic conditions than the controls. Based on the findings of this study, we propose that fol-BODIPY may serve as a tumor-targeting, hypoxia-activatable probe that allows for direct cancer monitoring both in vitro and in vivo.