1448244-87-8Relevant articles and documents
A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells
Bhuniya, Sankarprasad,Lee, Min Hee,Jeon, Hyun Mi,Han, Ji Hye,Lee, Jae Hong,Park, Nayoung,Maiti, Sukhendu,Kang, Chulhun,Kim, Jong Seung
, p. 7141 - 7143 (2013)
We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.