1206694-75-8

Basic information

• Product Name: (E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
• Synonyms: N-{(E)-[4-(benzyloxy)phenyl]methylidene}-4-fluoroaniline
• CAS NO: 1206694-75-8
• Molecular Formula: C₂₀H₁₆FNO
• Molecular Weight: 305.3455
• Mol File: 1206694-75-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline(1206694-75-8)
• EPA Substance Registry System: (E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline(1206694-75-8)

Safety Data

• Hazardous Substances Data: 1206694-75-8(Hazardous Substances Data)

Usage

Description

(E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline is an organic compound characterized by a fluorinated aniline ring connected to a benzylidene group. The (E) in its name signifies the configuration of the double bond in the benzylidene group, with substituents positioned on opposite sides. This unique structure and its properties make it a compound of interest in medicinal chemistry and material science.

Uses

Used in Pharmaceutical Industry:
(E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical industry, (E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline is utilized as a key intermediate in the production of various agrochemicals. Its incorporation into these compounds can lead to enhanced pest control and crop protection solutions.
Used in Material Science:
(E)-N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline also has potential applications in material science. Its unique structure and properties can be harnessed to develop new materials with specific characteristics, such as improved stability or reactivity, for use in various industrial applications.

Upstream product

• 100-39-0 benzyl bromide 
• 3382-63-6 (Z)-4-hydroxybenzylidene-4-fluorophenylamine 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 371-40-4 4-fluoroaniline 
• 123-08-0 4-hydroxy-benzaldehyde 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 100-44-7 benzyl chloride 
• 3382-63-6 N-(4-hydroxybenzylidene)-4-fluorobenzenamine 

Downstream Products

• 182824-73-3 (3R,4S)-4-(4-Benzyloxy-phenyl)-3-[(S)-2-(4-fluoro-phenoxy)-1-hydroxy-ethyl]-1-(4-fluoro-phenyl)-azetidin-2-one 
• 1240815-99-9 (Z)-N-(4-(benzyloxy)benzylidene)-4-fluoroaniline-N-oxide 
• 917392-16-6 N-{2-[3-(methoxy)-3-(oxo)-propyl]-3-(4-fluorophenylamino)-3-(4-benzyloxyphenyl)-1-oxo-propyl}-4-(S)-phenyloxazolidin-2-one 
• 221349-56-0 (3S,4S)-4-(4-Benzyloxy-phenyl)-3-((S)-1,2-dihydroxy-ethyl)-1-(4-fluoro-phenyl)-azetidin-2-one 
• 953805-24-8 4(S)-(4-benzyloxyphenyl)-1-(4-fluorophenyl)-3(R)-{2-[2-(4-fluorophenyI)-5,5-dimethyl-[1,3]-dioxan-2-yl]-ethyl}azetidine-2-one 
• 190595-65-4 (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one 
• 415960-63-3 N-(4-(benzyloxy)benzyl)-4-fluoroaniline 

Relevant articles and documents

A new class of ezetimibe derivative and its preparation method (by machine translation)

The present invention provides a new class of ezetimibe derivatives, characterized in that its structural formula as shown in formula I: The invention the ezetimibe derivatives improves the water-solubility of ezetimibe, more conducive to clinical use. (by machine translation)

Visible-Light Photocatalytic Synthesis of Amines from Imines via Transfer Hydrogenation Using Quantum Dots as Catalysts

CdSe/CdS core/shell quantum dots (QDs) can be used as stable and highly active photoredox catalysts for efficient transfer hydrogenation of imines to amines with thiophenol as a hydrogen atom donor. This reaction proceeds via a proton-coupled electron transfer (PCET) from the QDs conduction band to the protonated imine followed by hydrogen atom transfer from the thiophenol to the α-aminoalkyl radical. This precious metal free transformation is easy to scale up and can be carried out by a one-pot protocol directly from aldehyde, amine, and thiophenol. Additional advantageous features of this protocol include a wide substrate scope, high yield of the amine products, extremely low catalyst loading (0.001 mol %), high turnover number (105), and the mild reaction conditions of using visible light or sun light at room temperature in neutral media.

METHOD FOR PRODUCING EZETIMIBE AND INTERMEDIATE THEREOF

PROBLEM TO BE SOLVED: To provide a method for producing ezetimibe that is a cholesterol-lowering agent. SOLUTION: The present invention provides a method for producing ezetimibe (I) that generates intermediate (M1) and eliminates a protecting group. [R1 is a benzyl group and others, R2 is an ether protecting group such as a silyl ether protecting group]. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT