120681-07-4

Basic information

• Product Name: 2-Propenoyl chloride, 3-[4-(trifluoromethyl)phenyl]-, (2E)-
• CAS NO: 120681-07-4
• Molecular Formula: C10H6ClF3O
• Molecular Weight: 234.605
• Mol File: 120681-07-4.mol
• Article Data: 73

Chemical Properties

• CAS DataBase Reference: 2-Propenoyl chloride, 3-[4-(trifluoromethyl)phenyl]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 3-[4-(trifluoromethyl)phenyl]-, (2E)-(120681-07-4)
• EPA Substance Registry System: 2-Propenoyl chloride, 3-[4-(trifluoromethyl)phenyl]-, (2E)-(120681-07-4)

Safety Data

• Hazardous Substances Data: 120681-07-4(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 95123-61-8 (2E)-3-(4-trifluoromethylphenyl)prop-2-enal 
• 115093-99-7 (E)-3-(4-trifluoromethylphenyl)-2-propenamide 
• 2062-26-2 3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid 
• 79-37-8 oxalyl dichloride 
• 16642-92-5 4-(trifluoromethyl)cinnamic acid 

Downstream Products

• 88556-19-8 3-Phenyl-2-[(E)-3-(4-trifluoromethyl-phenyl)-acryloylamino]-propionic acid 
• 115093-99-7 (E)-3-(4-trifluoromethylphenyl)-2-propenamide 
• 870524-83-7 (R)-N-[(E)-4-CF₃C₆H₄CHCHC(O)]-4-phenyl-1,3-oxazolidin-2-one 
• 1343408-07-0 3-(4-trifluoromethyl-phenyl)-acryloyl azide 
• 410086-28-1 7-(trifluoromethyl)-1,2-dihydroisoquinolin-1-one 
• 1584132-13-7 (E)-3-(4-(trifluoromethyl)phenyl)acryloyl cyanide 
• 1584131-98-5 7-(4-nitrophenylsulfonyl)-10-(4-(trifluoromethyl)phenyl)-7-azaspiro[4.5]decane-1,6,8-trione 
• 1488155-76-5 6β-(4-(trifluoromethyl)cinnamoyl)-morphinamine 
• 1488155-89-0 6β-(4-(trifluoromethyl)cinnamoyl)-codeinamine 
• 1448548-14-8 (Z)-3-iodo-N,N-diisopropyl-3-(4-(trifluoromethyl)phenyl)acrylamide 
• 1448547-85-0 (E)-N,N-diisopropyl-3-(4-(trifluoromethyl)phenyl)acrylamide 
• 1395045-39-2 (E)-N-(but-3-yn-1-yl)-3-(4-trifluoromethylphenyl)acrylamide 
• 1395045-80-3 (1E,2E)-methyl N-(but-3-yn-1-yl)-3-[(4-trifluoromethyl)phenyl]prop-2-enimidothioate 
• 1395045-81-4 (1Z,2E)-methyl N-(but-3-yn-1-yl)-3-[(4-trifluoromethyl)phenyl]prop-2-enimidothioate 

Relevant articles and documents

Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives

This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and acylation reaction. The cytotoxicity was assessed by the MTT assay. Flowcytometry was performed to determine the cell cycle arrest, apoptosis, ROS levels and the loss of MMP. The ratios of GSH/GSSG and the MDA levels were determined by using UV spectrophotometry. The results revealed that introducing substitutions (CF3, OCF3, F) on the meta- of the benzyl ring of barbituric acid derivatives led to a considerable increase in the antiproliferative activities compared with that of corresponding ortho- and para-substituted barbituric acid derivatives. Mechanism investigation implied that the 1c could increase the ROS and MDA level, decrease the ratio of GSH/GSSG and MMP, and lead to cell cycle arrest. Further research is needed for structural optimization to enhance hydrophilicity, thereby improve the biological activity of these compounds.

(E)-4-methyl-2-(4-(trifluoromethyl) styryl) oxazole compound as well as preparation method and application thereof

The invention belongs to the technical field of medicines, relates to a compound with anti-tumor activity and a specific chemical structure, and in particular relates to an (E)-4-methyl-2-(4-(trifluoromethyl) styryl) oxazole compound as well as a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R1 group is substituted by a 2-position, 3-position or 4-position mono-substituted fluorine atom, methyl, chlorine atom, methoxy group, bromine atom or an unsubstituted group; and the R2 group is substituted by a 2-position, 3-position or 4-position mono-substituted methoxy group, a chlorine atom or an unsubstituted group. Pharmacological studies show that the compound has certain inhibitory activity on human non-small cell lung cancer A549 cells, can be used for preparing anti-tumor drugs, and opens up a new way for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

Cinnamyl-containing rupestonic acid methyl ester derivative as well as preparation method and application of rupestonic acid methyl ester derivative

The invention relates to a cinnamyl-containing rupestonic acid methyl ester derivative as well as a preparation method and application thereof, the derivative is prepared by the following steps: reacting rupestonic acid with dimethyl sulfate to obtain rupestonic acid methyl ester, and then obtaining 2-hydroxyl rupestonic acid methyl ester under the oxidation of camphor sulfonyl acridine. and then reacting with cinnamyl chloride under the catalysis of DMAP to obtain 20 rupestonic acid methyl ester derivatives containing cinnamyl groups. The method has the advantages of mild reaction conditions and simple experimental steps. The obtained 1d-20d rupestonic acid methyl ester derivatives containing the cinnamyl groups are subjected to a preliminary in-vitro anti-influenza A H3N2 virus activity test. Experimental results show that the compounds show good activity in 7d, 15d and 18d, and can be used as drugs for resisting influenza A H3N2 virus.