121225-27-2

Basic information

• Product Name: L-Proline, N-benzoyl-L-leucyl-, methyl ester
• CAS NO: 121225-27-2
• Molecular Formula: C19H26N2O4
• Molecular Weight: 346.426
• Mol File: 121225-27-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Proline, N-benzoyl-L-leucyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-benzoyl-L-leucyl-, methyl ester(121225-27-2)
• EPA Substance Registry System: L-Proline, N-benzoyl-L-leucyl-, methyl ester(121225-27-2)

Safety Data

• Hazardous Substances Data: 121225-27-2(Hazardous Substances Data)

Upstream product

• 1466-83-7 N-benzoyl-L-leucine 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 3005-60-5 N-benzoyl-L-leucine methyl ester 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 98-88-4 benzoyl chloride 
• 1466-83-7 N-benzoyl-DL-leucine 
• 25163-98-8 4-isobutyl-2-phenyloxazol-5(4H)-one 

Downstream Products

• 502761-28-6 RA-1004 
• 502761-27-5 1-tert-butyloxycarbonylamino-3-[(N-benzoyl)-L-leucyl-L-prolyl-amino]propane 
• 658053-34-0 N-benzoyl-D,L-leucyl-L-proline 

Relevant articles and documents

Dynamic kinetic resolution of N-benzoyl-DL-amino acids via peptide bond forming reactions

Dynamic kinetic resolution (DKR) was demonstrated in the carbodiimide-mediated couplings of N-benzoyl-DL-amino acids with L-amino acid esters: the yields of the D-L-peptides significantly exceeded 50% in some cases. N-benzoyl-DL-t-leucine afforded the D-L-peptide almost exclusively (up to 96% yield) in the reaction with methyl L-prolinate, which is the most efficient DKR obtained in the field of amino acids and derivatives.

Cyanopeptide analogues: New lead structures for the design and synthesis of new thrombin inhibitors

This contribution deals with the structure-based design and syntheses of the new serine protease inhibitors RA-1001 and RA-1002, which are analogues of the blue-green algae derived cyanopeptide aeruginosin 98-B. Both compounds inhibit thrombin with Ki values of 5.6 μM and 8.7 μM, respectively.