658053-34-0

Basic information

• Product Name: L-Proline, N-benzoyl-L-leucyl-
• CAS NO: 658053-34-0
• Molecular Formula: C18H24N2O4
• Molecular Weight: 332.4
• Mol File: 658053-34-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Proline, N-benzoyl-L-leucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-benzoyl-L-leucyl-(658053-34-0)
• EPA Substance Registry System: L-Proline, N-benzoyl-L-leucyl-(658053-34-0)

Safety Data

• Hazardous Substances Data: 658053-34-0(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 61-90-5 L-leucine 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 1466-83-7 N-benzoyl-L-leucine 
• 3005-60-5 N-benzoyl-L-leucine methyl ester 
• 121225-27-2 N-benzoyl-L-leucyl-L-proline methyl ester 

Downstream Products

• 1374962-81-8 N-benzoyl-D,L-leucyl-L-proline-[(4-cyanophenyl)methyl]amide 
• 502761-28-6 RA-1004 
• 502761-27-5 1-tert-butyloxycarbonylamino-3-[(N-benzoyl)-L-leucyl-L-prolyl-amino]propane 

Relevant articles and documents

PROLINAMIADE DERIVATIVES AS THROMBIN INHIBITOR, PREPRARATION METHOD AND APPLICATION THEREOF

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.

Cyanopeptide analogues: New lead structures for the design and synthesis of new thrombin inhibitors

This contribution deals with the structure-based design and syntheses of the new serine protease inhibitors RA-1001 and RA-1002, which are analogues of the blue-green algae derived cyanopeptide aeruginosin 98-B. Both compounds inhibit thrombin with Ki values of 5.6 μM and 8.7 μM, respectively.