126275-15-8

Basic information

• Product Name: 4-methyl-3-phenylpentanoyl chloride
• Synonyms: 4-methyl-3-phenylpentanoyl chloride
• CAS NO: 126275-15-8
• Molecular Weight: 210.704
• Mol File: 126275-15-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-methyl-3-phenylpentanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3-phenylpentanoyl chloride(126275-15-8)
• EPA Substance Registry System: 4-methyl-3-phenylpentanoyl chloride(126275-15-8)

Safety Data

• Hazardous Substances Data: 126275-15-8(Hazardous Substances Data)

Upstream product

• 51690-50-7 4-methyl-3-phenylpentanoic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 611-69-8 rac-2-methyl-1-phenylpropan-1-ol 
• 57181-82-5 4-bromo-isobutylbenzene 
• 100613-11-4 (2-methyl-1-phenyl-propyl)-malonic acid 
• 59771-18-5 diethyl 2-(2-methyl-1-phenylpropyl)malonate 
• 100-52-7 benzaldehyde 
• 621-82-9 Cinnamic acid 
• 611-70-1 phenyl isopropyl ketone 
• 92301-37-6 (+/-)-Ethyl 3-hydroxy-4-methyl-3-phenylpentanoate 
• 72277-17-9 (+/-)-ethyl 4-methyl-3-phenylpentanoate 

Downstream Products

• 185674-72-0 2-Diazo-5-phenyl-6-methylheptan-3-one 
• 72277-17-9 (+/-)-ethyl 4-methyl-3-phenylpentanoate 
• 1019003-37-2 (R)-ethyl 4-methyl-3-phenylpentanoate 
• 22573-54-2 (R)-3-phenyl-4-methylpentanoic acid 
• 22573-51-9 (S)-(-)-3-phenyl-4-methylpentanoic acid 
• 51690-50-7 4-methyl-3-phenylpentanoic acid 
• 20894-20-6 5,5-dimethyl-4-phenylpyrrolidin-2-one 
• 137585-97-8 4-Methyl-3-phenyl-pentanoic acid (3aR,5R,6S,6aR)-2,2-dimethyl-5-phenethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 137585-88-7 4-Methyl-3-phenyl-pentanoic acid (3aR,5R,6S,6aR)-5-benzyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 83303-62-2 1-Diazo-5-methyl-4-phenyl-hexan-2-one 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.

Stereocontrol in the intramolecular Buchner reaction of diazoketones

Rhodium(II) acetate catalysed intramolecular Buchner cyclisation of a series of diazoketones 1 proceeds with excellent diastereoselectivity to produce the trans substituted azulenones 2, which exist as a rapidly equilibrating cycloheptatriene-norcaradiene system, from which the norcaradiene tautomers can be efficiently trapped as PTAD cycloadducts 4. The cyclisation-cycloaddition sequence can be conducted in either a stepwise or a tandem process, leading to the pentacyclic systems 4 as a single diastereomer in each case. In the reaction of diazoketone If intramolecular cyclopropanation competes with cyclisation to the aromatic ring.