100613-11-4

Basic information

• Product Name: (2-methyl-1-phenyl-propyl)-malonic acid
• Synonyms: (2-methyl-1-phenyl-propyl)-malonic acid
• CAS NO: 100613-11-4
• Molecular Weight: 236.268
• Mol File: 100613-11-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2-methyl-1-phenyl-propyl)-malonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methyl-1-phenyl-propyl)-malonic acid(100613-11-4)
• EPA Substance Registry System: (2-methyl-1-phenyl-propyl)-malonic acid(100613-11-4)

Safety Data

• Hazardous Substances Data: 100613-11-4(Hazardous Substances Data)

Upstream product

• 59771-18-5 diethyl 2-(2-methyl-1-phenylpropyl)malonate 
• 5652-68-6 diethyl 2-(2-methylpropylidene)malonate 
• 100-52-7 benzaldehyde 
• 57181-82-5 4-bromo-isobutylbenzene 
• 611-69-8 rac-2-methyl-1-phenylpropan-1-ol 

Downstream Products

• 126275-15-8 4-methyl-3-phenylpentanoyl chloride 
• 185674-72-0 2-Diazo-5-phenyl-6-methylheptan-3-one 
• 51690-50-7 4-methyl-3-phenylpentanoic acid 

Relevant articles and documents

Stereocontrol in the intramolecular Buchner reaction of diazoketones

Rhodium(II) acetate catalysed intramolecular Buchner cyclisation of a series of diazoketones 1 proceeds with excellent diastereoselectivity to produce the trans substituted azulenones 2, which exist as a rapidly equilibrating cycloheptatriene-norcaradiene system, from which the norcaradiene tautomers can be efficiently trapped as PTAD cycloadducts 4. The cyclisation-cycloaddition sequence can be conducted in either a stepwise or a tandem process, leading to the pentacyclic systems 4 as a single diastereomer in each case. In the reaction of diazoketone If intramolecular cyclopropanation competes with cyclisation to the aromatic ring.