127310-66-1

Basic information

• Product Name: (1-benzylazetidine-2,4-diyl)dimethanol
• Synonyms: (1-benzylazetidine-2,4-diyl)dimethanol;cis-(1-Benzyl-4-hydroxymethyl-azetidin-2-yl)-methanol;Cis-1-Benzylazetidine-2,4-Diyl)Dimethanol;[1-benzyl-4-(hydroxymethyl)azetidin-2-yl]methanol;Cis-1-Benzylazetidine-2,4-Diyl)Dimethanol(WXC00460)
• CAS NO: 127310-66-1
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.26888
• Mol File: 127310-66-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 342.9°C at 760 mmHg
• Flash Point: 173.3°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 2.79E-05mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (1-benzylazetidine-2,4-diyl)dimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-benzylazetidine-2,4-diyl)dimethanol(127310-66-1)
• EPA Substance Registry System: (1-benzylazetidine-2,4-diyl)dimethanol(127310-66-1)

Safety Data

• Hazardous Substances Data: 127310-66-1(Hazardous Substances Data)

Usage

General Description

"(1-benzylazetidine-2,4-diyl)dimethanol" is a chemical compound. It features a four-membered azetidine ring, which makes it a part of the azetidine family. Azetidines are often used in the synthesis of pharmaceuticals and other biologically active compounds. The methanol functionalities and the benzyl group in its structure suggest it may have potential applications as a reactant in organic synthesis and could be used for the preparation of more complex molecules. However, there isn't much specific information available about this particular compound, so it is difficult to determine its exact properties, uses, and potential hazards without further experimental data or references.

InChI:InChI=1/C12H17NO2/c14-8-11-6-12(9-15)13(11)7-10-4-2-1-3-5-10/h1-5,11-12,14-15H,6-9H2

Upstream product

• 121050-02-0 cis-1-benzylazetidine-2,4-dicarboxylic acid dibenzyl ester 
• 174309-28-5 2,4-diethyl (2R,4S)-1-benzylazetidine-2,4-dicarboxylate 
• 870-78-0 2,4-dibromoglutaric acid diethyl ester 
• 100-46-9 benzylamine 
• 2873-74-7 gloutaric dichloride 
• 3479-80-9 α,α'-dibromoglutaric acid 
• 121050-10-0 (2S,4R)-1-Benzyl-4-methylselanylcarbonyl-azetidine-2-carboxylic acid benzyl ester 
• 121050-01-9 2,4-dibromoglutaric acid dibenzyl ester 
• 121050-02-0 (±)-trans-dibenzyl 2,2'-(1-benzylazetidine-2,4-diyl)diacetate 
• 108-55-4 glutaric anhydride, 
• 121049-89-6 α,α'-dibromoglutaric anhydride 
• 29548-85-4 2,4-dibromoglutaryl chloride 
• 116652-68-7 1,5-diethyl (2R,4S)-2,4-dibromopentanedioate 
• 96960-31-5 meso-α,α'-dibromoglutaric anhydride 

Downstream Products

• 351075-49-5 (2S,4R)-4-acetoxymethyl-1-benzylazetidine-2-methanol 
• 351075-60-0 (2R,4R)-1-benzyl-4-methylazetidine-2-methanol 
• 351075-64-4 (2R,4R)-α,α-diphenyl-4-methylazetidine-2-methanol 
• 351075-59-7 (2R,4S)-2-(acetoxymethyl)-1-benzyl-4-(methanesulfonyloxy)methylazetidine 
• 351075-50-8 (2R,4S)-1-benzyl-4-{[(t-butyldimethyl)silyloxy]methyl}azetidine-2-methanol 
• 351075-63-3 (2R,4R)-1-(t-butoxycarbonyl)-α,α-diphenyl-4-methylazetidine-2-methanol 
• 351075-70-2 (2R,4S)-2-(acetoxymethyl)-1-benzyl-4-{[(t-butyldimethyl)silyloxy]methyl}azetidine 
• 1400593-18-1 6-benzyl-3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane 
• 1400593-17-0 C₁₄H₂₁NO₆S₂ 

Relevant articles and documents

SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY

The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake

Lobelane analogs that incorporate a central piperidine or pyrrolidine moiety have previously been reported by our group as potent inhibitors of VMAT2 function. Further central ring size reduction of the piperidine moiety in lobelane to a four-membered het

Synthesis of Optically Active N-Benzyl-2,4-Bis(hydroxymethyl) Substituted Azetidines by Lipase Catalyzed Acetylations

Both cis- and trans-N-benzyl-azetidine-2,4-dimethanols 5 and 6 were prepared and submitted to acetylation in organic solvents catalyzed by lipases.Asymmetrization of diol 5 gave the corresponding monoacetate 7, while double sequential kinetic resolution of racemic 6 gave optically enriched diol 6b and its enantiomer as the corresponding diacetate 10a.Optimized reaction conditions furnished 7, 6b and 10a with e.e.>99percent.