128612-44-2

Basic information

• Product Name: Phenol, 3,5-dimethoxy-, methanesulfonate
• CAS NO: 128612-44-2
• Molecular Formula: C9H12O5S
• Molecular Weight: 232.257
• Mol File: 128612-44-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 3,5-dimethoxy-, methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3,5-dimethoxy-, methanesulfonate(128612-44-2)
• EPA Substance Registry System: Phenol, 3,5-dimethoxy-, methanesulfonate(128612-44-2)

Safety Data

• Hazardous Substances Data: 128612-44-2(Hazardous Substances Data)

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1262526-31-7 2-(3,5-dimethoxyphenyl)-3-fluoropyridine 1-oxide 
• 34967-24-3 3,5-dimethoxybenzylamine 
• 22976-40-5 1,3-dimethoxy-5-pentylbenzene 
• 19179-31-8 3,5-dimethoxy-benzonitrile 
• 1126479-69-3 1-deuterio-3,5-dimethoxybenzene 
• 1032400-18-2 2-(3,5-dimethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 140650-63-1 2-Methanesulfonyloxy-4,6-dimethoxy-benzenesulfonic acid 
• 140650-64-2 4-Methanesulfonyloxy-2,6-dimethoxy-benzenesulfonic acid 

Relevant articles and documents

Synthesis method of 3, 5-dihydroxypentene benzene

The invention provides a synthesis method of 3, 5-dihydroxypentene benzene. The synthesis method comprises the following steps: reacting 3, 5-dimethoxyphenol used as a raw material with a sulfonate halide reagent to generate sulfonate, carrying out cross-coupling reaction with a nucleophilic reagent to introduce amyl, and finally reducing methoxyl into phenolic hydroxyl, thereby obtaining the product 3, 5-dihydroxypentene benzene. The synthesis method solves the defects of high cost, complex route, low yield, poor purity and the like of the traditional process.

NiCl2(dppe)-Catalyzed Cross-Coupling of Aryl Mesylates, Arenesulfonates, and Halides with Arylboronic Acids

An investigation of the NiCl2(dppe)-, NiCl2(dppb)-, NiCl2(dppf)-, NiCl2(PCy3)2-, and NiCl2(PPh3)2- catalyzed cross-coupling of the previously unreported aryl mesylates, and of aryl arenesulfonates, chlorides, bromides, and iodides containing electron-withdrawing and electron-donating substituents with aryl boronic acids, in the absence of a reducing agent, is reported. NiCl2(dppe) was the only catalyst that exhibited high and solvent-independent activity in the two solvents investigated, toluene and dioxane. NiCl2(dppe) with an excess of dppe, NiCl 2(dppe)/dppe, was reactive in the cross-coupling of electron-poor aryl mesylates, tosylates, chlorides, bromides, and iodides. This catalyst was also efficient in the cross-coupling of aryl bromides and iodides containing electron-donating substituents. Most surprisingly, the replacement of the excess dppe from NiCl2(dppe)/dppe with excess PPh3 generated NiCl2(dppe)/PPh3, which was found to be reactive for the cross-coupling of both electron-rich and electron-poor aryl mesylates and chlorides. Therefore, the solvent-independent reactivity of NiCl2(dppe) provides an inexpensive and general nickel catalyst for the cross-coupling of aryl mesylates, tosylates, chlorides, bromides, and iodides with aryl boronic acids.