129799-11-7

Basic information

• Product Name: 4-Cbz-piperazine-2-carboxylate methyl ester
• Synonyms: PIPERAZINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER;N-4-CBZ-PIPERAZINE-2-CARBOXYLATE METHYL ESTER;METHYL-4-CBZ PIPERAZINE-2-CARBOXYLATE;MethylN-4-Cbz-piperazine-2-carboxylate;4-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;N-4-CBZ-piperazine-2-carboxyiate methyl ester;Methyl 4-(benzyloxycarbonyl)piperazine-2-carboxylate;4-Cbz-piperazine-2-carboxylate methyl ester
• CAS NO: 129799-11-7
• Molecular Formula: C₁₄H₁₈N₂O₄
• Molecular Weight: 278.3
• Product Categories: API intermediates
• Mol File: 129799-11-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 406.5 °C at 760 mmHg
• Flash Point: 199.7 °C
• Appearance: /
• Density: 1.212 g/cm³
• Vapor Pressure: 1.88E-09mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.43±0.40(Predicted)
• CAS DataBase Reference: 4-Cbz-piperazine-2-carboxylate methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cbz-piperazine-2-carboxylate methyl ester(129799-11-7)
• EPA Substance Registry System: 4-Cbz-piperazine-2-carboxylate methyl ester(129799-11-7)

Safety Data

• Hazardous Substances Data: 129799-11-7(Hazardous Substances Data)

Usage

General Description

4-Cbz-piperazine-2-carboxylate methyl ester is a chemical compound used in the pharmaceutical industry. It is a derivative of piperazine, a heterocyclic organic compound. 4-Cbz-piperazine-2-carboxylate methyl ester is commonly used as an intermediate in the synthesis of various pharmaceuticals, particularly antipsychotic and antidepressant drugs. It is also used as a building block for the production of other important chemical compounds. The methyl ester group in the compound makes it more stable and allows for easy manipulation in synthetic processes. Its chemical structure and properties make it a valuable component in the production of numerous medications and other chemical products.

InChI:InChI=1/C13H16N2O4/c16-12(17)11-8-15(7-6-14-11)13(18)19-9-10-4-2-1-3-5-10/h1-5,11,14H,6-9H2,(H,16,17)

Upstream product

• 2758-98-7 2-methoxycarbonyltetrahydropyrazine 
• 501-53-1 benzyl chloroformate 
• 171504-98-6 O₁,O₄-di-tert-butyl O₂-methyl piperazine-1,2,4-tricarboxylate 
• 181955-79-3 N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid 

Downstream Products

• 129799-14-0 4-benzyl 1-(tert-butyl) 2-methyl piperazine-1,2,4-tricarboxylate 
• 129799-12-8 methyl 4-benzyloxycarbonyl-1-(3,4,5-trimethoxybenzoyl)-piperazine-2-carboxylate 
• 225517-81-7 1-benzyl 3-methyl (3S)-piperazine-1,3-dicarboxylate 
• 1394957-81-3 1-benzyl 3-methyl (3R)-4-(3-mesitylpropanoyl)piperazine-1,3-dicarboxylate 
• 405175-79-3 (R)-4-((benzyloxy)carbonyl)piperazine-2-carboxylic acid 

Relevant articles and documents

Piperazine compound and application thereof in preparation of chemokine receptor CCR2 antagonist

The invention relates to a piperazine compound as shown in a formula (I) and an application of the piperazine compound in preparation of a chemokine receptor CCR2 antagonist or a medicine for treatingCCR2-mediated diseases.

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Trisubstituted piperazine compounds, their production and use

Novel trisubstituted piperazine compounds of the formula (I): wherein A is an optionally substituted phenyl group, an optionally substituted condensed polycyclic hydrocarbon group, an optionally substituted hetero-cyclic group or a styryl group of the formula:, Ar - CR4 = CR5 - wherein Ar is an optionally substituted phenyl group, and R4 and R5 are independently hydrogen or a lower alkyl group, X is methylene group, carbonyl group or thiocarbonyl group, G is a group of the formula:, nZ-R6 wherein n is an integer of 0 to 2, Z is a chemical bond, O, S, SO, SO2, CO, COO, CONR7 or NR7 (wherein R7 is hydrogen, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group or a lower alkoxycarbonyl group), and R6 is hydrogen, a lower alkyl group, a lower haloalkyl group or a lower alkenyl group, provided that, when n is 0 and Z is chemical bond, R6 is not hydrogen or a lower alkyl group, and R1, R2 and R3 are independently a lower alkyl group, and salts thereof, are useful as a platelet activating factor antagonist.