2758-98-7

Basic information

• Product Name: 2-Piperazinecarboxylic acid methyl ester
• Synonyms: 2-Piperazinecarboxylic acid methyl ester;Methyl piperazine-2-carboxylate;Methylpiperazine-2-carboxylate2HCl;2-Methoxycarbonylpiperazine
• CAS NO: 2758-98-7
• Molecular Formula: C₆H₁₂N₂O₂
• Molecular Weight: 144.17
• Product Categories: pharmacetical
• Mol File: 2758-98-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 223.6 °C at 760 mmHg
• Flash Point: 89 °C
• Appearance: /
• Density: 1.059 g/cm³
• Vapor Pressure: 0.0953mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: 2-8°C
• PKA: 8.05±0.40(Predicted)
• CAS DataBase Reference: 2-Piperazinecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperazinecarboxylic acid methyl ester(2758-98-7)
• EPA Substance Registry System: 2-Piperazinecarboxylic acid methyl ester(2758-98-7)

Safety Data

• Hazardous Substances Data: 2758-98-7(Hazardous Substances Data)

Usage

General Description

2-Piperazinecarboxylic acid methyl ester, also known as methyl 2-piperazinecarboxylate, is a chemical compound commonly used in the pharmaceutical industry. It is a methyl ester derivative of 2-piperazinecarboxylic acid, which is a building block for many pharmaceutical drugs. 2-Piperazinecarboxylic acid methyl ester is known for its potential use as a precursor in the synthesis of various pharmaceuticals, such as antihistamines and antipsychotic drugs. It also has potential applications in the development of new drug candidates. However, careful handling and storage of this chemical are necessary due to its potential hazards, and it should only be used by qualified personnel in a controlled laboratory setting.

InChI:InChI=1/C6H12N2O2/c1-10-6(9)5-4-7-2-3-8-5/h5,7-8H,2-4H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 2762-32-5 piperazine-2-carboxylic acid 
• 98-97-5 2-pyrazylcarboxylic acid 
• 171504-98-6 O₁,O₄-di-tert-butyl O₂-methyl piperazine-1,2,4-tricarboxylate 
• 107-15-3 ethylenediamine 
• 292638-85-8 acrylic acid methyl ester 
• 129799-15-1 piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 67-56-1 methanol 

Downstream Products

• 129799-08-2 tert-butyl methyl piperazine-1,3-dicarboxylate 
• 241499-35-4 1-(3-Methyl-butyl)-piperazine-2-carboxylic acid methyl ester 
• 241499-37-6 1-(3-methyl-butyl)-4-methyl-2-piperazinecarboxylic acid 
• 241499-36-5 4-Methyl-1-(3-methyl-butyl)-piperazine-2-carboxylic acid methyl ester 
• 241499-34-3 4-(3-Methyl-butyl)-piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 
• 129799-11-7 1-benzyl 3-methyl piperazine-1,3-dicarboxylate 
• 171504-98-6 O₁,O₄-di-tert-butyl O₂-methyl piperazine-1,2,4-tricarboxylate 
• 1445976-19-1 methyl 1-tert-butoxycarbonyl-4-(N-tert-butoxycarbonylglycyl)piperazine-2-carboxylate 
• 1449505-54-7 C₁₄H₁₆N₂O₄ 
• 1449504-85-1 4-(3-formylbenzoyl)piperazine-2-carboxylic acid 
• 1404538-71-1 C₃₁H₃₃ClN₆O₅ 

Relevant articles and documents

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

IMIDAZO [4, 5 - B] PYRIDINE DERIVATIVES AS ALK AND JAK MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.