131245-86-8

Basic information

• Product Name: (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane
• Synonyms: (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane
• CAS NO: 131245-86-8
• Molecular Weight: 216.234
• Mol File: 131245-86-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane(131245-86-8)
• EPA Substance Registry System: (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane(131245-86-8)

Safety Data

• Hazardous Substances Data: 131245-86-8(Hazardous Substances Data)

Upstream product

• 38551-69-8 1,3,5-triacetoxy-cyclohexane 
• 131245-85-7 (1S,3R,5S)-5-Benzyloxy-cyclohexane-1,3-diol 
• 50409-12-6 cis,cis-1,3,5-trihydroxycyclohexane 
• 140363-93-5 (1R,3S,5S)-1-acetoxy-5-benzyloxy-3-methanesulfonyloxycyclohexane 
• 130256-36-9 (1S,3S,5R)-1-acetoxy-5-benzyloxy-3-cyclohexanol 
• 130256-34-7 meso-1,3-cis,3,5-cis-1,3-diacetoxy-5-benzyloxycyclohexane 
• 130256-34-7 (1R,3R,5R)-1,3-diacetoxy-5-benzyloxycyclohexane 
• 108-24-7 acetic anhydride 
• 13314-30-2 cis-1,3,5-cyclohexane-triol 

Downstream Products

• 131245-88-0 (3S,5R)-5-acetoxy-1-cyclohexen-3-ol 
• 131245-89-1 (3S,5R)-5-acetoxy-3-benzoyloxy-1-cyclohexene 
• 332097-67-3 (3S,5S)-3,5-diacetoxy-cyclohexan-1-one 
• 131245-87-9 (3S,5R)-3,5-diacetoxy-1-cyclohexene 
• 241151-12-2 (1R,3R)-5-[(2E,9Z)-12,12,12-trifluoro-11-hydroxy-7,7-dimethyl-11-trifluoromethyl-dodeca-2,9-dienylidene]cyclohexane-1,3-diol 
• 241151-12-2 (1R,3R)-5-((2Z,9Z)-12,12,12-Trifluoro-11-hydroxy-7,7-dimethyl-11-trifluoromethyl-dodeca-2,9-dienylidene)-cyclohexane-1,3-diol 
• 332097-76-4 Methanesulfonic acid (3S,5S)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl ester 
• 332097-70-8 ethyl ((3R,5R)-3,5-diacetoxy-cyclohexylidene)-acetate 
• 332854-82-7 Methanesulfonic acid (3S,5S)-3,5-dihydroxy-cyclohexyl ester 
• 139356-39-1 (1R,3R)-1,3-bis((tert-butyldimethyl)silanyloxy)-5-[2-(diphenylphosphinoyl)-ethylidene]cyclohexane 
• 139356-37-9 [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol 

Relevant articles and documents

Process for preparing retiferol derivatives

A new process prepares retiferol derivatives of formula I: wherein A is —C ≡C— or —CH═CH—, and R1and R2are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula 1I with compounds of f

Multiselective enzymatic reactions for the synthesis of protected homochiral cis- and trans-1,3,5-cyclohexanetriols

For the synthesis of the potentially antipsoriatic vitamin D derivative 3 (Ro 65-2299) an efficient and multiselective enzymatic step had been developed in which the easily accessible trans-1,3,5-triacetoxy-cyclohexane 5 was selectively monohydrolyzed in the presence of the cis-isomer 8 to give (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane 6 in high enantiomeric excess (>99%) and yield (84%). Furthermore, for the synthesis of the enantiomer of 3, a simple and efficient enzymatic procedure for the asymmetric acetylation of cis-1,5-dihydroxy-3-(tert-butyldimethylsilanoxy)-cyclohexane 10 in an anhydrous organic solvent providing (1R,3S,5S)-1-acetoxy-3-hydroxy-5-(tert-butyldimethylsilanoxy)-cyclohexane 11 in >99% ee and quantitative yield is described. Copyright (C) 2000 Elsevier Science Ltd.

Asymmetric Hydrolysis of cis,cis-5-5Benzyloxy-1,3-diacetoxy-cyclohexane and its application to the synthesis of chiral lactone moiety in compactin

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