241151-12-2

Basic information

• Product Name: 5-[12,12,12-Trifluoro-11-hydroxy-7,7-dimethyl-11-(trifluoromethyl)dodeca-2(E),9(Z)-dienylidene]cyclohexane-1(R),3(R)-diol
• Synonyms: BAL-2299; Ro-65-2299
• CAS NO: 241151-12-2
• Molecular Formula: C₂₁H₃₀F₆O₃
• Molecular Weight: 444.46185
• Mol File: 241151-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[12,12,12-Trifluoro-11-hydroxy-7,7-dimethyl-11-(trifluoromethyl)dodeca-2(E),9(Z)-dienylidene]cyclohexane-1(R),3(R)-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[12,12,12-Trifluoro-11-hydroxy-7,7-dimethyl-11-(trifluoromethyl)dodeca-2(E),9(Z)-dienylidene]cyclohexane-1(R),3(R)-diol(241151-12-2)
• EPA Substance Registry System: 5-[12,12,12-Trifluoro-11-hydroxy-7,7-dimethyl-11-(trifluoromethyl)dodeca-2(E),9(Z)-dienylidene]cyclohexane-1(R),3(R)-diol(241151-12-2)

Safety Data

• Hazardous Substances Data: 241151-12-2(Hazardous Substances Data)

Upstream product

• 139356-39-1 (1R,3R)-1,3-bis((tert-butyldimethyl)silanyloxy)-5-[2-(diphenylphosphinoyl)-ethylidene]cyclohexane 
• 332097-61-7 (7Z)-10,10,10-trifluoro-5,5-dimethyl-9-(triethylsilanyloxy)-9-trifluoromethyl-dec-7-en-1-al 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 131245-86-8 (1R,3R)-1,3-diacetoxy-5-hydroxy-cyclohexane 
• 139356-37-9 [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol 
• 13314-30-2 cis-1,3,5-cyclohexane-triol 
• 332097-58-2 8-tert-butyloxy-4,4-dimethyl-octan-2-one 
• 332097-67-3 (3S,5S)-3,5-diacetoxy-cyclohexan-1-one 
• 332097-70-8 ethyl ((3R,5R)-3,5-diacetoxy-cyclohexylidene)-acetate 
• 241151-45-1 (7Z)-10,10,10-trifluoro-9-hydroxy-5,5-dimethyl-9-trifluoromethyl-dec-7-en-1-al 
• 241151-44-0 (7Z)-10,10,10-trifluoro-5,5-dimethyl-9-trifluoromethyl-dec-7-en-1,9-diol 
• 332097-60-6 (3Z)-10-tert-butyloxy-1,1,1-trifluoro-6,6-dimethyl-2-trifluoromethyl-dec-3-en-2-ol 
• 332097-59-3 10-tert-butyloxy-1,1,1-trifluoro-6,6-dimethyl-2-trifluoromethyl-dec-3-yn-2-ol 
• 332097-86-6 (2E,9Z)-2-(12,12,12-trifluoro-7,7-dimethyl-11-triethylsilanyloxy-11-trifluoromethyl-dodeca-2,9-diene-1-sulfonyl)-benzothiazole 

Relevant articles and documents

Novel versatile approach to an enantiopure 19-nor, des-C,D vitamin D3 derivative

A short and efficient de novo route to the des-C,D vitamin D3 derivative 3 (Ro 65-2299), a potential antipsoriatic, has been developed. This route features an assembly strategy so far unexplored in vitamin D chemistry involving a modified Julia olefination of the A-ring ketone 30 and the 2-benzothiazolyl sulfone 60. Construction of the A-ring building block was accomplished by an efficient three-step route starting from the meso trans-1,3,5-cyclohexane triol (26), which was desymmetrized by a highly selective enzymatic mono-hydrolysis of the corresponding triacetate 27 followed by oxidation of the alcohol 29 to give the homochiral diacetoxy ketone 30 (ee=99.5%) in 83% overall yield. Furthermore, we found efficient and practical syntheses of the 5-acetoxy-2-cyclohexenone (31) and its enantiomer 32, both new building blocks useful for natural product synthesis.

Process for preparing retiferol derivatives

A new process prepares retiferol derivatives of formula I: wherein A is —C ≡C— or —CH═CH—, and R1and R2are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula 1I with compounds of f