1315571-17-5

Basic information

• Product Name: 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole
• Synonyms: 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole
• CAS NO: 1315571-17-5
• Molecular Weight: 247.656
• Mol File: 1315571-17-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole(1315571-17-5)
• EPA Substance Registry System: 6-chloro-2-(4-fluorophenyl)benzo[d]oxazole(1315571-17-5)

Safety Data

• Hazardous Substances Data: 1315571-17-5(Hazardous Substances Data)

Upstream product

• 31928-44-6 2-bromo-4-chloroiodobenzene 
• 824-75-9 p-fluorobenzamide 
• 101398-11-2 N-(2,4-Dichloro-phenyl)-4-fluoro-benzamide 
• 28443-50-7 2-amino-5-chlorophenol 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 397-54-6 2-(4-fluorophenyl)benzoxazole 
• 456-22-4 4-Fluorobenzoic acid 
• 95-55-6 2-amino-phenol 

Relevant articles and documents

Access to 2-(het)aryl and 2-styryl benzoxazoles via palladium-catalyzed aminocarbonylation of aryl and vinyl bromides

A sequential one-pot procedure for the synthesis of either 2-(hetero)aryl or 2-styryl benzoxazoles is reported, starting from aryl and vinyl bromides, respectively, involving an initial aminocarbonylation with 2-aminophenols as nucleophiles followed by an acid mediated ring closure to generate the heterocycle. The methodology displays a broad substrate scope in moderate to excellent yields and can be exploited for 13C-isotope labeling. Finally, this carbonylative protocol was applied to the synthesis of a potential Alzheimer's plaque binder and a selective PPAR antagonist including site-specific labeling with 13C-carbon monoxide.

Copper-catalysed intramolecular O-arylation: A simple and efficient method for benzoxazole synthesis

A wide range of 2-substituted benzoxazoles can be efficiently synthesized from N-(2-iodo-/bromo-phenyl)benzamides, and even the less reactive N-(2-chlorophenyl)benzamides, via Cu-catalysed intramolecular coupling cyclization reactions using methyl 2-methoxybenzoate as the ligand under mild reaction conditions. In addition, the benzoxazoles can be easily prepared from the primary amides coupling with o-dihalobenzenes in a single step. This journal is

Mesoporous poly(melamine-formaldehyde): A green and recyclable heterogeneous organocatalyst for the synthesis of benzoxazoles and benzothiazoles using dioxygen as oxidant

A simple, highly efficient, and sustainable strategy for the synthesis of benzoxazole and benzothiazole derivatives was developed by using inexpensive, green, readily available, and recyclable mesoporous poly(melamine-formaldehyde) as a green, heterogeneous organocatalyst. The corresponding substituted benzoxazoles and benzothiazoles were obtained in good to excellent yields by aerobic oxidation of o-substituted aminobenzenes with various aldehydes under dioxygen atmosphere. The catalyst can be completely recovered through simple filtration to be reused more than six times without significant loss of catalytic activity.