131791-82-7Relevant articles and documents
Catalytic asymmetric oxidative carbonylation-induced kinetic resolution of sterically hindered benzylamines to chiral isoindolinones
Mu, Qiu-Qi,Nie, Yi-Xue,Li, Hang,Bai, Xing-Feng,Liu, Xue-Wei,Xu, Zheng,Xu, Li-Wen
, p. 1778 - 1781 (2021/02/27)
A highly enantioselective kinetic resolution of sterically hindered benzylamines has been achieved for the first time through transition-metal-catalyzed oxidative carbonylation, in which the new KR strategy offered a new approach to afford chiral isoindolinones (er up to 97?:?3) and the origin of chemoselectivity and stereoselectivity was confirmed by density functional theory (DFT) calculations.
Effect of the 4′-substituted phenylalanine moiety of sansalvamide A peptide on antitumor activity
Liu, Shouxin,Yang, Yihua,Zhao, Cuiran,Huang, Jing,Han, Chunyu,Han, Jianrong
, p. 463 - 467 (2014/04/17)
Eight sansalvamide A peptide analogues with 4′-fluoride, 4′-chloride, 4′-bromide, 4′-iodide, and 4′- methoxyphenylalanine moieties were synthesized. The effect of these para-substitutions of sansalvamide A peptide on their cytotoxicity was evaluated using HCT-116, MDA-MB-231, HT-29, HCT-15, K562, HeLa, and A549 cell lines. The 4′-methoxyphenylalanine analog of sansalvamide A peptide was found to be a promising antitumor agent.
Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs
Ghosh, Arun K.,Dawson, Zachary L.,Moon, Deuk Kyu,Bai, Ruoli,Hamel, Ernest
scheme or table, p. 5104 - 5107 (2010/10/04)
Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their abi