132482-05-4

Basic information

• Product Name: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE
• Synonyms: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE;(R)-tert-Butyl 2-(2-Methoxy-2-oxoethyl)pyrrolidine-1-carboxylate
• CAS NO: 132482-05-4
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 143.185
• Mol File: 132482-05-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 190.215°C at 760 mmHg
• Flash Point: 68.84°C
• Appearance: /
• Density: 1.006g/cm³
• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: 1.44
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE(132482-05-4)
• EPA Substance Registry System: (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE(132482-05-4)

Safety Data

• Hazardous Substances Data: 132482-05-4(Hazardous Substances Data)

Usage

General Description

(R)-Methyl 2-(pyrrolidin-2-yl)acetate, also known as R-MA, is a chemical compound with the molecular formula C8H13NO2. It is an ester derived from the amino acid proline and has a pyrrolidine ring structure. (R)-METHYL 2-(PYRROLIDIN-2-YL)ACETATE has been studied for its potential use in pharmaceuticals and as a chiral building block in organic synthesis. It has also been investigated for its potential use in the development of new drug candidates and as a precursor for the synthesis of natural products. However, further research is needed to fully understand the potential applications and effects of (R)-Methyl 2-(pyrrolidin-2-yl)acetate.

InChI:InChI=1/C7H13NO2/c1-10-7(9)5-6-3-2-4-8-6/h6,8H,2-5H2,1H3/t6-/m1/s1

Upstream product

• 186581-53-3 diazomethane 
• 34619-03-9 tert-butyldicarbonate 
• 147-85-3 L-proline 
• 67-56-1 methanol 
• 101130-03-4 tert-butyl (S)-2-(diazoacetyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 223118-68-1 tert-butyl (E)-2-(2-methoxy-2-oxoethylidene)pyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 86971-65-5 pyrrolidin-2-ylidene-acetic acid methyl ester 
• 141874-26-2 N-Boc-(S)-proline chloride 
• 259868-83-2 (S)-pyrrolidin-2-ylacetic acid methyl ester hydrochloride 
• 56502-01-3 (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 61810-78-4 (-)-2-((S)-1-methylpyrrolidin-2-yl)ethanol 
• 88790-38-9 (2S)-tert-butyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate 
• 132482-06-5 tert-butyl (2R)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylate 
• 53912-83-7 [(2S)-pyrrolidin-2-yl]acetic acid methyl ester 
• 191528-63-9 [(S)-1-(2-Azido-benzoyl)-pyrrolidin-2-yl]-acetaldehyde 
• 191528-62-8 (2-Azido-phenyl)-[(S)-2-(2-hydroxy-ethyl)-pyrrolidin-1-yl]-methanone 
• 191528-61-7 Carbonic acid 2-[(S)-1-(2-azido-benzoyl)-pyrrolidin-2-yl]-ethyl ester methyl ester 
• 526-64-7 laburnine 
• 340040-67-7 methyl 2-[(2R)-pyrrolidin-2-yl]acetate hydrochloride 
• 201038-72-4 (R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine 
• 261901-57-9 SB 269970 A 
• 1269622-73-2 (R)-2-(3-phenyl-[1,2,4]oxadiazol-5-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1269622-74-3 3-phenyl-5-(R)-1-pyrrolidin-2-ylmethyl-[1,2,4]oxadiazole 
• 1338968-17-4 C₂₉H₄₁NO₃ 

Relevant articles and documents

LIGAND EFFECTS IN ENANTIOFACE DIFFERENTIATING 1,4 ADDITION TO 1,3 DIPHENYL-2 PROPEN-1 ONE

The extent of enantiomeric excess in the β-methylation of chalcone by chiral cuprates is shown to depend strongly on small structural modifications of the ligands, all of which are derived from the basic carbon framework of L-prolinol.Enantiomeric excesses up to 88percent have been realised.

Diastereoselective synthesis of (-)-1-methyl-(3S,4R)-3,4-bis((2S)-N- (tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone by an asymmetric Michael reaction

Beginning with enantiomerically pure L-proline, (-)-1-methyl-(3S,4R)- 3,4-bis((2S)-N-(tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone was prepared in diastereomerically pure form. Taking advantage of the chiral induction of the L-proline derivatives, the intermolecular Michael reaction, used to build the pyrrolidinone ring, was carried out stereoselectively.

Iminium ion-enamine cascade cyclizations: Facile access to structurally diverse azacyclic compounds and natural products

A one-pot, mild, two-component iminium ion-enamine cascade reaction to construct structurally diverse azacyclic frameworks from l-proline and l-pipecolic acid, and its application to indolizidine and quinolizidine alkaloids and azasteroids, is reported.

A systematic study of chiral homoprolinols and their derivatives in the catalysis of enantioselective addition of diethylzinc to aldehydes

Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the literature references, we have observed that the γ-amino alcohols are superior to the corresponding β-amino alcohols when the nitrogen and the oxygen are unsubstituted. Among the homoprolinols we tested, 2b gave the best results (45-88% yields, 44-81% ee) in the addition reactions. To the best of our knowledge, 2b has been noticed as one of the most efficient γ-amino alcohol catalysts based on pyrrolidine framework.