132976-75-1

Basic information

• Product Name: methyl 5-acetylamino-6-chloro-2H-1-benzopyran-8-carboxylate
• CAS NO: 132976-75-1
• Molecular Weight: 281.696
• Mol File: 132976-75-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 189.2 °C
• Boiling Point: 512.5±50.0 °C(Predicted)
• Density: 1.384±0.06 g/cm3(Predicted)
• CAS DataBase Reference: methyl 5-acetylamino-6-chloro-2H-1-benzopyran-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-acetylamino-6-chloro-2H-1-benzopyran-8-carboxylate(132976-75-1)
• EPA Substance Registry System: methyl 5-acetylamino-6-chloro-2H-1-benzopyran-8-carboxylate(132976-75-1)

Safety Data

• Hazardous Substances Data: 132976-75-1(Hazardous Substances Data)

Upstream product

• 4136-97-4 methyl 4-aminosalicylate 
• 65-49-6 4-Aminosalicylic acid 
• 24190-77-0 methyl 4-acetylamino-5-chloro-2-hydroxybenzoate 
• 89481-87-8 methyl 4-(acetylamino)-5-chloro-2-(2-propynyloxy)benzoate 
• 101-84-8 diphenylether 
• 152880-16-5 methyl 4-acetylamino-2-propargyloxybenzoate 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 

Relevant articles and documents

AMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-hydroxytryptamine 4 (5-HT4) receptor.

HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptors.

Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist

The supply route to GlaxoSmithKline's 5HT4 receptor agonist 1 centred on the construction of key benzopyran fragment 2. Our attempts to define the final manufacturing route for this component are described through a series of disconnections. The systematic approach undertaken towards the construction of the benzopyran skeleton focused on cycli- sation strategies from appropriate precursors and evaluation of the performance of the key steps.