152880-16-5Relevant articles and documents
Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist
Rassias, Geracimos,Stevenson, Neil G.,Curtis, Neil R.,Northall, John M.,Gray, Matthew,Prodger, Jeremy C.,Walker, Andrew J.
scheme or table, p. 92 - 98 (2010/04/28)
The supply route to GlaxoSmithKline's 5HT4 receptor agonist 1 centred on the construction of key benzopyran fragment 2. Our attempts to define the final manufacturing route for this component are described through a series of disconnections. The systematic approach undertaken towards the construction of the benzopyran skeleton focused on cycli- sation strategies from appropriate precursors and evaluation of the performance of the key steps.
