89481-87-8

Basic information

• Product Name: Methyl 4-acetamido-5-chloro-2-(prop-2-yn-1-yloxy)benzoate
• Synonyms: Methyl 4-acetamido-5-chloro-2-(prop-2-yn-1-yloxy)benzoate;methyl 4-(acetylamino)-5-chloro-2-(2-propynyloxy)benzoate;Methyl5-chloro-4-acetamido-2-(prop-2-yn-1-yloxy)benzoate
• CAS NO: 89481-87-8
• Molecular Formula: C₁₃H₁₂ClNO₄
• Molecular Weight: 281.7
• Mol File: 89481-87-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 4-acetamido-5-chloro-2-(prop-2-yn-1-yloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-acetamido-5-chloro-2-(prop-2-yn-1-yloxy)benzoate(89481-87-8)
• EPA Substance Registry System: Methyl 4-acetamido-5-chloro-2-(prop-2-yn-1-yloxy)benzoate(89481-87-8)

Safety Data

• Hazardous Substances Data: 89481-87-8(Hazardous Substances Data)

Upstream product

• 152880-16-5 methyl 4-acetylamino-2-propargyloxybenzoate 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 24190-77-0 methyl 4-acetylamino-5-chloro-2-hydroxybenzoate 
• 106-96-7 propargyl bromide 
• 65-49-6 4-Aminosalicylic acid 
• 4136-97-4 methyl 4-aminosalicylate 

Downstream Products

• 202664-71-9 methyl 4-acetylamino-5-chloro-2-methylbenzofuran-7-carboxylate 
• 132976-75-1 methyl 5-acetylamino-6-chloro-2H-1-benzopyran-8-carboxylate 
• 202664-80-0 methyl 4-acetylamino-5-chloro-2-methylbenzofuran-7-carboxylate 
• 24190-77-0 methyl 4-acetylamino-5-chloro-2-hydroxybenzoate 

Relevant articles and documents

AMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-hydroxytryptamine 4 (5-HT4) receptor.

HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptors.

Implementation of a high-temperature claisen approach for early phase delivery of a benzopyran derivative

Control of trace inorganics and an understanding of reaction kinetics and impurity generation proved critical in allowing safe and reliable scale-up of a high-temperature Claisen reaction in support of multikilogram manufacture of a key chromene intermediate 4. Implementation of a Medicinal Chemistry route allowed for rapid early phase delivery of 1 to support early clinical studies.