134372-99-9Relevant articles and documents
Novel P2X7 receptor antagonists.
Alcaraz,Baxter,Bent,Bowers,Braddock,Cladingboel,Donald,Fagura,Furber,Laurent,Lawson,Mortimore,McCormick,Roberts,Robertson
, p. 4043 - 4046 (2007/10/03)
The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distribution of the P2X(7) receptor in inflammatory cells, most notabl
A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates
Miwa, Tetsuo,Hitaka, Takenori,Akimoto, Hiroshi
, p. 1696 - 1701 (2007/10/02)
A novel and efficient synthetic method for the synthesis of pyrrolopyrimidine antifolates is described.The key reaction of this method is the photo-initiated free radical addition of bromomalononitrile or ethyl bromocyanoacetate to an enol ether to afford the backbone skeleton of the targeted antifolate molecule.The key intermediates 3 or 4 are smoothly converted to the pyrrolopyrimidine antifolates 1 or 2 in three steps and in high overall yield.