146943-27-3

Basic information

• Product Name: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-, 1,1-dimethylethyl ester
• CAS NO: 146943-27-3
• Molecular Formula: C15H18O4
• Molecular Weight: 262.306
• Mol File: 146943-27-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-, 1,1-dimethylethyl ester(146943-27-3)
• EPA Substance Registry System: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-, 1,1-dimethylethyl ester(146943-27-3)

Safety Data

• Hazardous Substances Data: 146943-27-3(Hazardous Substances Data)

Upstream product

• 120363-13-5 tert-butyl 4-iodobenzoate 
• 292638-85-8 acrylic acid methyl ester 
• 619-58-9 4-iodobenzoic acid 
• 88641-55-8 tetrabutylammonium chloride monohydrate 
• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 389625-36-9 tert-butyl 4-(3-methoxy-1-methyl-3-oxopropyl)benzoate 
• 126931-31-5 methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate 
• 86208-18-6 3-<4-(tert-butoxycarbonyl)phenyl>propionic acid 
• 146943-43-3 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 
• 146943-41-1 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester 
• 134373-06-1 4-[4,4-Dimethoxy-3-(2,4,6-triamino-pyrimidin-5-yl)-butyl]-benzoic acid tert-butyl ester 
• 137281-39-1 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid 
• 134373-01-6 4-(4,4-Dicyano-3-dimethoxymethyl-butyl)-benzoic acid tert-butyl ester 
• 134373-00-5 tert-butyl 4-(4-methoxy-3-butenyl)benzoate 
• 134372-99-9 3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal 
• 126931-32-6 tert-Butyl 4-(3-hydroxy-1-propyl)benzoate 
• 150586-02-0 diethyl N-{4-[1-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-propenyl]benzoyl}-L-glutamate 
• 150586-00-8 diethyl N-{4-[1-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamate 
• 150585-98-1 diethyl N-{4-[1-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate 

Relevant articles and documents

Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: Design and synthesis of one-carbon bridge derivatives

A series of novel pyrrolo[2,3-d]pyrimidine derivatives was designed and synthesized as thymidylate synthase (TS) inhibitors. Molecular design was performed on the human TS complex model built on the basis of the reported structure of TS-deoxyuridinemonoph

A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates

A novel and efficient synthetic method for the synthesis of pyrrolopyrimidine antifolates is described.The key reaction of this method is the photo-initiated free radical addition of bromomalononitrile or ethyl bromocyanoacetate to an enol ether to afford the backbone skeleton of the targeted antifolate molecule.The key intermediates 3 or 4 are smoothly converted to the pyrrolopyrimidine antifolates 1 or 2 in three steps and in high overall yield.