135067-18-4

Basic information

• Product Name: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane
• Synonyms: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane
• CAS NO: 135067-18-4
• Molecular Weight: 316.632
• Mol File: 135067-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane(135067-18-4)
• EPA Substance Registry System: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane(135067-18-4)

Safety Data

• Hazardous Substances Data: 135067-18-4(Hazardous Substances Data)

Upstream product

• 138602-95-6 (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 2043-61-0 cyclohexanecarbaldehyde 
• 138490-38-7 (+/-)-3-(tert-butyldimethylsilyloxy)-3-cyclohexyl-2-methyl-1-propene 
• 138490-39-8 (2S*,3R*)-3-(tert-butyldimethylsilyloxy)-3-cyclohexyl-2-methylpropanol 
• 138490-37-6 (±)-1-cyclohexyl-2-methylprop-2-en-1-ol 

Downstream Products

• 138604-11-2 (2R,3S,6S,7S,10R)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 138490-36-5 (2S,3R,6R,7S,10R)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 138602-95-6 (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol 
• 144969-59-5 (2R,3S)-3-Cyclohexyl-2-methyl-3-trimethylsilanyloxy-propan-1-ol 
• 144969-58-4 (1R,2S)-1-Cyclohexyl-2-methyl-3-trimethylsilanyloxy-propan-1-ol 
• 138603-03-9 (2R,3R)-3-Cyclohexyl-3-hydroxy-2-methyl-propionic acid 
• 138490-51-4 (2R,3R)-3-cyclohexyl-3-hydroxy-2-methylpropanal 
• 78604-73-6 (-)-methyl (2R,3R)-3-cyclohexyl-3-hydroxy-2-methylpropionate 
• 138490-36-5 (2R,3S,6S,7S,10R)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 138490-36-5 (2R,3S,6S,7R,10S)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 105401-07-8 (1R,2S)-1-cyclohexyl-2-methyl-1,3-propanediol 

Relevant articles and documents

Stereoselective Acetalization of 1,3-Alkanediols by l-Menthone: Application to the Resolution of Racemic 1,3-Alkanediols and to the Determination of the Absolute Configuration of Enantiomeric 1,3-Alkanediols

A general and reliable method for the resolution of racemic 1,3-alkanediols, which involves their conversion into diastereomeric spiroacetals derived from l-menthone, is described.Thus, the reaction of the bis-O-trimethylsilyl derivatives of racemic 1,3-alkanediols with l-menthone in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate affords the diastereomeric spiroacetals 3 and 4.The two can be readily separated by silica gel column chromatography.Hydrolysis of each diastereomer under acidic conditions liberates the corresponding enantiomerically pure diol.An empirically derived correlation of configuration and 1H NMR chemical shifts for spiroacetals 3 and 4 has been developed which is rationalized based on long-range effects due to the magnetic anisotropy inherent to the menthane ring in a rigid spiroacetal conformation.The method described here should be widely applicable to the determination of the absolute configuration of various 1,3-alkanediols.