138602-95-6

Basic information

• Product Name: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol
• Synonyms: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol
• CAS NO: 138602-95-6
• Molecular Weight: 172.268
• Mol File: 138602-95-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol(138602-95-6)
• EPA Substance Registry System: (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-propanediol(138602-95-6)

Safety Data

• Hazardous Substances Data: 138602-95-6(Hazardous Substances Data)

Upstream product

• 6305-59-5 ethyl 3-hydroxy-3-cyclohexyl-2-methylpropanoate 
• 79-03-8 propionyl chloride 
• 2043-61-0 cyclohexanecarbaldehyde 
• 135067-18-4 (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane 
• 138490-39-8 (2S*,3R*)-3-(tert-butyldimethylsilyloxy)-3-cyclohexyl-2-methylpropanol 
• 138490-37-6 (±)-1-cyclohexyl-2-methylprop-2-en-1-ol 
• 138490-38-7 (+/-)-3-(tert-butyldimethylsilyloxy)-3-cyclohexyl-2-methyl-1-propene 

Downstream Products

• 105401-07-8 (1R,2S)-1-cyclohexyl-2-methyl-1,3-propanediol 
• 138604-11-2 (2R,3S,6S,7S,10R)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 138490-36-5 (2S,3R,6R,7S,10R)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 135067-18-4 (1R*,2S*)-1-cyclohexyl-2-methyl-1,3-bis(trimethylsiloxy)propane 
• 138603-03-9 (2R,3R)-3-Cyclohexyl-3-hydroxy-2-methyl-propionic acid 
• 138490-51-4 (2R,3R)-3-cyclohexyl-3-hydroxy-2-methylpropanal 
• 78604-73-6 (-)-methyl (2R,3R)-3-cyclohexyl-3-hydroxy-2-methylpropionate 
• 138490-36-5 (2R,3S,6S,7R,10S)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 138490-36-5 (2R,3S,6S,7S,10R)-2-Cyclohexyl-7-isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undecane 
• 1047670-90-5 (4S,5R)-2,2,5-trimethyl-4-cyclohexyl-[1,3]-dioxane 
• 79388-54-8 2-Cyclohexyl-3-methyl-oxetane 

Relevant articles and documents

Copper-Catalyzed Stereospecific Hydroboration of Internal Allylic Alcohols

An effective Cu-catalyzed stereospecific hydroboration of aliphatic and aromatic 1,1,2-trisubstituted internal allylic alcohols has been reported. This reaction proceeds via a silyl ether transient protection of allylic alcohols and subsequent stereospecific hydroboration. Followed by an oxidative workup, an array of acyclic, cyclic, and heterocyclic 1,3-diols was synthesized in good to excellent yields with good functional group tolerance and excellent diastereomeric ratios (> 20:1).

Combined proline-surfactant organocatalyst for the highly diastereo- and enantioselective aqueous direct cross-aldol reaction of aldehydes

(Chemical Equation Presented) Why not combine the two? The asymmetric direct aldol reaction of two different aldehydes was catalyzed by a combined proline-surfactant organic catalyst in the presence of water. A stable emulsion was formed in the reaction mixture, and the aldols were obtained with excellent diastereo- and enantioselectivities (see scheme).

Aldol reactions on solid phase. Sc(OTf)3-catalyzed aldol reactions of polymer-supported silyl enol ethers with aldehydes providing convenient methods for the preparation of 1,3-diol, β-hydroxy carboxylic acid, and β-hydroxy aldehyde libraries

Aldol reactions on solid phase have been achieved. In the presence of a catalytic amount of scandium triflate (Sc(OTf)3), polymer-supported silyl enol ethers reacted with aldehydes to afford the corresponding β-hydroxy thioester derivatives, which were reduced to 1,3-diol and β-hydroxy aldehyde derivatives, or hydrolyzed to β-hydroxy carboxylic acid derivatives.