13534-89-9 Usage
Description
2,3-Dibromopyridine is an organic compound characterized by its light yellow crystalline structure. It is a derivative of pyridine, a heterocyclic compound, with two bromine atoms attached at the 2nd and 3rd positions. 2,3-Dibromopyridine is known for its chemical reactivity and is widely utilized in various synthetic applications.
Uses
Used in Chemical Synthesis:
2,3-Dibromopyridine is used as a synthetic intermediate for the production of substituted pyridines. The bromine-magnesium exchange reaction allows for the creation of a wide range of pyridine derivatives with diverse applications in the chemical and pharmaceutical industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-Dibromopyridine is used as a key building block for the synthesis of halopyridinylboronic acids and esters. These compounds are valuable in the development of new drugs, particularly those targeting neurological and cardiovascular conditions. The unique structural features of 2,3-dibromopyridine enable the design of novel therapeutic agents with improved efficacy and selectivity.
Used in Material Science:
2,3-Dibromopyridine's chemical properties also make it a useful component in the development of new materials with specific properties. Its reactivity and structural characteristics can be exploited to create advanced materials for various applications, such as sensors, catalysts, and advanced polymers.
Check Digit Verification of cas no
The CAS Registry Mumber 13534-89-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,3 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13534-89:
(7*1)+(6*3)+(5*5)+(4*3)+(3*4)+(2*8)+(1*9)=99
99 % 10 = 9
So 13534-89-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H3Br2N/c6-4-2-1-3-8-5(4)7/h1-3H
13534-89-9Relevant articles and documents
Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions
Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 5565 - 5570 (2019/10/22)
A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.
Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids
Cottet, Fabrice,Marull, Marc,Lefebvre, Olivier,Schlosser, Manfred
, p. 1559 - 1568 (2007/10/03)
As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
