52200-48-3 Usage
Description
3-Bromo-2-chloropyridine is an organic compound with the chemical formula C5H3BrClN. It is synthesized from 3-amino-2-chloropyridine or 2-chloro-3-pyridinamine and exhibits chemical properties as yellow, elongated needle-like crystals.
Uses
Used in Pharmaceutical Industry:
3-Bromo-2-chloropyridine is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its application reason is due to its unique chemical structure, which allows for the creation of a range of molecules with potential therapeutic properties.
Used in Chemical Synthesis:
3-Bromo-2-chloropyridine is used as a building block in the synthesis of complex organic molecules. It serves as a key component in the production of various compounds, such as:
1. Acetylenic dipyridone: 3-Bromo-2-chloropyridine is used as a starting material for the synthesis of acetylenic dipyridone, which may have potential applications in medicinal chemistry.
2. 3-Ethynyl-2-(phenylmethoxy)-pyridine: 3-Bromo-2-chloropyridine is synthesized using 3-bromo-2-chloropyridine and is potentially useful in the development of new pharmaceutical agents.
3. Nemertelline: 3-Bromo-2-chloropyridine is utilized in the synthesis of nemertelline, a compound that may have biological activities of interest.
4. Ortho-chlorodiheteroarylamine: 3-Bromo-2-chloropyridine is synthesized from 3-bromo-2-chloropyridine and is used in the development of new chemical entities with potential applications in various fields.
5. 2-Chloro-N-(2,3,7-trimethylbenzo[b]thien-6-yl)pyridin-3-amine: 3-Bromo-2-chloropyridine is used in the synthesis of this compound, which may have potential applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 52200-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,2,0 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52200-48:
(7*5)+(6*2)+(5*2)+(4*0)+(3*0)+(2*4)+(1*8)=73
73 % 10 = 3
So 52200-48-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrClN/c6-4-2-1-3-8-5(4)7/h1-3H
52200-48-3Relevant articles and documents
Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions
Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 5565 - 5570 (2019/10/22)
A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.
Large-scale solvent-free chlorination of hydroxy-pyrimidines,-pyridines,- pyrazines and-amides using equimolar POCl3
Wang, Han,Wen, Kun,Wang, Le,Xiang, Ye,Xu, Xiaocheng,Shen, Yongjia,Sun, Zhihua
experimental part, p. 4533 - 4544 (2012/06/30)
Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines,-quinoxalines, or even-amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
Bromine-lithium exchange under non-cryogenic conditions: TMSCH 2Li-LiDMAE promoted C-2 lithiation of 2,3-dibromopyridine
Gros, Philippe C.,Elaachbouni, Fatima
supporting information; experimental part, p. 4813 - 4815 (2009/03/12)
The first C-2 selective bromine-lithium exchange in 2,3-dibromopyridine was performed at 0°C in toluene using the TMSCH2Li-LiDMAE reagent. The Royal Society of Chemistry.
