135569-28-7

Basic information

• Product Name: Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-
• Synonyms: 4-iodophenylcyclopentylcarboxylic acid;1-(p-iodophenyl)cyclopentanecarboxylic acid
• CAS NO: 135569-28-7
• Molecular Formula: C12H13IO2
• Molecular Weight: 316.139
• Mol File: 135569-28-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-(135569-28-7)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-(135569-28-7)

Safety Data

• Hazardous Substances Data: 135569-28-7(Hazardous Substances Data)

Upstream product

• 15250-46-1 ethyl (4-iodophenyl)acetate 
• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 52648-77-8 1-(4-nitro-phenyl)-cyclopentanecarboxylic acid 
• 91640-63-0 1-(p-aminophenyl)cyclopentanecarboxylic acid 

Downstream Products

• 135569-31-2 Iodocaramiphen 

Relevant articles and documents

Synthesis of a potential M1 muscarinic agent [76Br] bromocaramiphen

[76Br]bromocaramiphen was prepared from the iodo-analogue by a Cu+ nucleophilic bromodeiodination exchange. The radiolabelling yield was 40-45%. The radiochemical and chemical purities assessed by radio-TLC and HPLC were 98%. The precursor, iodocaramiphen, was synthesized from commercially available 1-phenylcyclopentanecarboxylic acid with a 10% overall yield in a 5 step procedure. This synthesis includes the formation of 1-(p-nitrophenyl)-, 1-(p-aminophenyl)- and 1-(p-iodophenyl) cyclopemane carboxylic acid. In vivo studies in rats showed high uptake in brain. A 10% decrease was observed by coinjecting with the radiotracer a cold load of QNB, a non subtype selective muscarinic ligand. The metabolite study performed in the pons tissues indicated that there was still 92% of unchanged radiotracer 30 mm p.i. After coinjection of dextrometorphan, a sigma ligand, a reduction of the radioactivity uptake by 20 to 27% was observed in the pons, the cortex, the striatum and the cerebellum. These data suggest that [76Br]bromocaramiphen is not a potential probe for investigating the status of central M1 muscarinic receptors because of its high lipophilicity (log P7 4 = 2.4) and its affinity for sigma sites.

1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA INHIBITORS

The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.