91640-63-0

Basic information

• Product Name: AKOS BC-0227
• Synonyms: ASISCHEM D50963;AKOS BC-0227;1-(4-AMINOPHENYL)-CYCLOPENTANECARBOXYLIC ACID;1-(4-aminophenyl)cyclopentane-1-carboxylic acid
• CAS NO: 91640-63-0
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.255
• Mol File: 91640-63-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS BC-0227(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BC-0227(91640-63-0)
• EPA Substance Registry System: AKOS BC-0227(91640-63-0)

Safety Data

• Hazardous Substances Data: 91640-63-0(Hazardous Substances Data)

Upstream product

• 52648-77-8 1-(4-nitro-phenyl)-cyclopentanecarboxylic acid 
• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 115279-73-7 1-(4-aminophenyl)cyclopentane-1-carbonitrile 

Downstream Products

• 135569-29-8 1-(p-cyanophenyl)cyclopentanecarboxylic acid 
• 135569-28-7 1-(p-iodophenyl)cyclopentanecarboxylic acid 
• 135569-31-2 Iodocaramiphen 
• 135569-33-4 2-(diethylamino)ethyl 1-(p-cyanophenyl)cyclopentanecarboxylate 
• 1067192-35-1 1-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-cyclopentanecarboxylic acid 
• 1067189-49-4 1-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-cyclopentanecarboxylic acid methyl ester 
• 1067189-50-7 3,4-dimethoxy-N-[4-(1-methylcarbamoyl-cyclopentyl)-phenyl]-benzamide 

Relevant articles and documents

NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE

The present invention provides new compounds of formula I, wherein Q, R1, R2, R4, R5, R6, Xi, R7, R8, M and G1 nare defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.

Synthesis of a potential M1 muscarinic agent [76Br] bromocaramiphen

[76Br]bromocaramiphen was prepared from the iodo-analogue by a Cu+ nucleophilic bromodeiodination exchange. The radiolabelling yield was 40-45%. The radiochemical and chemical purities assessed by radio-TLC and HPLC were 98%. The precursor, iodocaramiphen, was synthesized from commercially available 1-phenylcyclopentanecarboxylic acid with a 10% overall yield in a 5 step procedure. This synthesis includes the formation of 1-(p-nitrophenyl)-, 1-(p-aminophenyl)- and 1-(p-iodophenyl) cyclopemane carboxylic acid. In vivo studies in rats showed high uptake in brain. A 10% decrease was observed by coinjecting with the radiotracer a cold load of QNB, a non subtype selective muscarinic ligand. The metabolite study performed in the pons tissues indicated that there was still 92% of unchanged radiotracer 30 mm p.i. After coinjection of dextrometorphan, a sigma ligand, a reduction of the radioactivity uptake by 20 to 27% was observed in the pons, the cortex, the striatum and the cerebellum. These data suggest that [76Br]bromocaramiphen is not a potential probe for investigating the status of central M1 muscarinic receptors because of its high lipophilicity (log P7 4 = 2.4) and its affinity for sigma sites.