52648-77-8

Basic information

• Product Name: 1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID
• Synonyms: 1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID
• CAS NO: 52648-77-8
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24
• Mol File: 52648-77-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID(52648-77-8)
• EPA Substance Registry System: 1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID(52648-77-8)

Safety Data

• Hazardous Substances Data: 52648-77-8(Hazardous Substances Data)

Usage

Description

1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID, with the molecular formula C12H11NO4, is a carboxylic acid featuring a cyclopentane ring and a nitrophenyl group. This chemical compound is recognized for its versatile reactivity and functional group properties, making it a valuable component in the synthesis of pharmaceuticals and organic compounds. Its potential as a building block for more complex organic molecules and its anti-inflammatory and analgesic properties also contribute to its significance in medicinal chemistry.

Uses

Used in Pharmaceutical Synthesis:
1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID is used as a key intermediate for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and reactivity allow for the creation of a wide range of molecules with diverse applications in the medical field.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID is used as a building block for constructing more complex organic molecules. Its potential in this area is attributed to its functional group properties and the ability to form meta-depside bonds, which are crucial for the development of novel therapeutic agents.
Used in Anti-inflammatory and Analgesic Applications:
1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID is used as an active compound for its anti-inflammatory and analgesic properties. Its potential in this application is due to its ability to modulate various signaling pathways involved in inflammation and pain, making it a subject of interest for the development of new medications to treat these conditions.
Used in Chemical Research:
1-(4-NITROPHENYL)CYCLOPENTANE-1-CARBOXYLICACID is also used as a research tool in chemical laboratories. Its unique structure and reactivity make it an ideal candidate for studying various chemical reactions and mechanisms, further expanding the understanding of organic chemistry and its applications in various industries.

Upstream product

• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 91392-33-5 1-(4-nitrophenyl)cyclopentane-1-carbonitrile 
• 104-03-0 4-nitrobenzeneacetic acid 
• 2945-08-6 methyl (4-nitrophenyl)acetate 
• 135569-19-6 methyl 1-(p-nitrophenyl)cyclopentanecarboxylate 

Downstream Products

• 422280-34-0 1-(4-nitro-phenyl)-cyclopentanecarbonyl chloride 
• 91640-63-0 1-(p-aminophenyl)cyclopentanecarboxylic acid 
• 492440-64-9 C₄₆H₅₉NO₁₁ 
• 492440-63-8 C₄₆H₅₉NO₁₁ 
• 1056938-04-5 1-(4-nitro-phenyl)-cyclopentanecarboxylic acid tert-butyl ester 
• 135569-28-7 1-(p-iodophenyl)cyclopentanecarboxylic acid 
• 135569-31-2 Iodocaramiphen 
• 135569-16-3 Nitrocaramiphen 
• 135569-20-9 methyl 1-(p-aminophenyl)cyclopentanecarboxylate 
• 135569-35-6 ethyl 1-(p-aminophenyl)cyclopentanecarboxylate 
• 135569-21-0 methyl 1-(p-1-pyrrolidinylphenyl)cyclopentanecarboxylate 
• 135569-19-6 methyl 1-(p-nitrophenyl)cyclopentanecarboxylate 
• 135569-25-4 1-(p-1-tetrazolylphenyl)cyclopentanecarboxylic acid 
• 135569-36-7 ethyl 1-(p-1-pyrrolidinylphenyl)cyclopentanecarboxylate 

Relevant articles and documents

Palladium(II)-Catalyzed C(sp2)-H Bond Activation/C-N Bond Cleavage Annulation of N-Methoxy Amides and Arynes

The Pd(II)-catalyzed C-H bond activation/C-N bond cleavage annulation reaction of N-alkyoxyamide aryne is developed to synthesize 9,10-dihydrophenanthrenone derivatives. This reaction exhibited good functional group compatibility with yields up to 92%. Detailed mechanistic studies showed that the key to C-N bond cleavage is the formed eight-membered palladacycle intermediate undergoing nucleophilic addition to the carbonyl group, which provides a new and practical way for N-alkoxyamide directed C-H bond activation.

1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA INHIBITORS

The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

Synthesis of a potential M1 muscarinic agent [76Br] bromocaramiphen

[76Br]bromocaramiphen was prepared from the iodo-analogue by a Cu+ nucleophilic bromodeiodination exchange. The radiolabelling yield was 40-45%. The radiochemical and chemical purities assessed by radio-TLC and HPLC were 98%. The precursor, iodocaramiphen, was synthesized from commercially available 1-phenylcyclopentanecarboxylic acid with a 10% overall yield in a 5 step procedure. This synthesis includes the formation of 1-(p-nitrophenyl)-, 1-(p-aminophenyl)- and 1-(p-iodophenyl) cyclopemane carboxylic acid. In vivo studies in rats showed high uptake in brain. A 10% decrease was observed by coinjecting with the radiotracer a cold load of QNB, a non subtype selective muscarinic ligand. The metabolite study performed in the pons tissues indicated that there was still 92% of unchanged radiotracer 30 mm p.i. After coinjection of dextrometorphan, a sigma ligand, a reduction of the radioactivity uptake by 20 to 27% was observed in the pons, the cortex, the striatum and the cerebellum. These data suggest that [76Br]bromocaramiphen is not a potential probe for investigating the status of central M1 muscarinic receptors because of its high lipophilicity (log P7 4 = 2.4) and its affinity for sigma sites.