13605-95-3

Basic information

• Product Name: 2-Benzyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-Benzyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 13605-95-3
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.31288
• Mol File: 13605-95-3.mol
• Article Data: 62

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Benzyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzyl-1,2,3,4-tetrahydroisoquinoline(13605-95-3)
• EPA Substance Registry System: 2-Benzyl-1,2,3,4-tetrahydroisoquinoline(13605-95-3)

Safety Data

• Hazardous Substances Data: 13605-95-3(Hazardous Substances Data)

Upstream product

• 35674-56-7 2-benzyl-isoquinolinium; chloride 
• 15787-39-0 2-benzylisoquinolin-2-ium iodide 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 100-39-0 benzyl bromide 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 781568-78-3 2-Benzyl-3,4-dihydro-isoquinolinium 
• 38602-73-2 2-benzylisoquinolinium 
• 17750-30-0 <4-(2)H>-1-benzyl-1,4-dihydronicotinamide 
• 6346-00-5 2-(2-hydroxyethyl)benzyl alcohol 
• 100-46-9 benzylamine 
• 65-85-0 benzoic acid 
• 82342-56-1 N-benzoyl-1,2,3,4-tetrahydroisoquinoline 
• 23277-04-5 2-benzylisoquinolin-2-ium bromide 
• 119-65-3 isoquinoline 

Downstream Products

• 87993-10-0 N-Methyl-N-benzyl-1,2,3,4-tetrahydroisochinoliniumiodid 
• 444588-09-4 2-benzyl-7-nitro-1,2,3,4-tetrahydroisoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 6772-61-8 2-(4-benzylphenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 110719-12-5 2-Benzyl-3,4-dihydro-2H-isoquinoline-1-thione 
• 82342-55-0 N-benzoyl-homophthalimide 
• 19716-56-4 1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 83491-16-1 N-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide 
• 88630-43-7 N-propyl-N'-tetrahydroisoquinolinylurea 
• 1150587-93-1 2-(2-benzyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-difluoro-1-phenylethanone 
• 1227403-19-1 1-allyl-2-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 1250257-29-4 2-benzyl-1-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline 
• 1260506-79-3 2-phenylmethyl-1-(1H-indol-3-yl)-1,2,3,4-tetrahydroisoquinoline 
• 1312343-57-9 C₂₂H₂₃NO 

Relevant articles and documents

Reductive amination of carboxylic acids and [11C]magnesium halide carboxylates

The reductive amination of carboxylic acids was shown to be promoted by 2-chloropyridine hydrochloride (3 eq). It allowed the one-pot preparation of N-alkylamines in yields up to 93% from carboxylic acid (1 eq), amine (1 eq) and sodium borohydride (5 molar eq). The reaction, carried out with [11C]magnesium halide carboxylates (11C, β+, t1/2:20 min), led to N-[11C]alkylamines in 20-25% radiochemical yields (decay corrected to the end of bombardment, 30 min preparation time from [11C]CO2). In this case, the addition of pyridinium salts led only to the corresponding [11C]carboxylic acids.

Catalyst-free multi-component cascade C-H-functionalization in water using molecular oxygen: An approach to 1,3-oxazines

Herein, catalyst-free 3-component reactions of naphthols, aldehydes, and tetrahydroisoquinolines to synthesize 1,3-oxazines is reported. The reaction is performed in H2O in the presence of O2 as the sole oxidant at 100 °C, which proceeds through the formation of 1-aminoalkyl-2-naphthols followed by selective α-C-H functionalization of tert-amine.

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

USE OF N-CHELATING RUTHENIUM COMPLEXES IN THE METATHESIS REACTION

The subject matter of the invention is the use of a ruthenium complex of the formula 1, wherein the individual substituents have meanings as indicated in the olefin metathesis reactions description, including a reaction selected from such as ring-closing