137869-15-9

Basic information

• Product Name: Oxazole, 4,5-dihydro-4,4-dimethyl-2-(2-phenyl-1-naphthalenyl)-
• CAS NO: 137869-15-9
• Molecular Formula: C21H19NO
• Molecular Weight: 301.388
• Mol File: 137869-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Oxazole, 4,5-dihydro-4,4-dimethyl-2-(2-phenyl-1-naphthalenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 4,5-dihydro-4,4-dimethyl-2-(2-phenyl-1-naphthalenyl)-(137869-15-9)
• EPA Substance Registry System: Oxazole, 4,5-dihydro-4,4-dimethyl-2-(2-phenyl-1-naphthalenyl)-(137869-15-9)

Safety Data

• Hazardous Substances Data: 137869-15-9(Hazardous Substances Data)

Upstream product

• 94321-29-6 2-(2-methoxy-1-naphthyl)oxazoline 
• 51439-58-8 2-methoxy-1-naphthoic acid chloride 
• 94321-75-2 2-Methoxy-naphthalene-1-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide 
• 947-62-6 2-methoxy-1-naphthoic acid 
• 3401-47-6 1-bromo-2-methoxynaphthalene 
• 591-51-5 phenyllithium 

Downstream Products

• 137869-22-8 2-phenyl-1-naphthaldehyde 

Relevant articles and documents

Regiospecific synthesis of polysubstituted naphthalenes via oxazoline-mediated nucleophilic aromatic substitutions and additions

An efficient procedure for the selective functionalization of several positions of 2-methoxynaphthalene is described. Nucleophilic aromatic substitutions were carried out by displacing both a methoxy group and a neutral amine ortho to an oxazoline 6. 4-Substituted naphthalenes 8 were obtained from nucleophilic aromatic addition of an allyllithium species to a position para to the oxazoline 6. The resultant dihydronaphthalenes were converted to the fully aromatic systems 9 or alternatively substituted in the 2-position to form 10. Reductive cleavage of the oxazoline moities in 7 and 9 proceeded smoothly, producing the substituted naphthaldehydes 11.