51439-58-8

Basic information

• Product Name: 2-methoxynaphthalene-1-carbonyl chloride
• Synonyms: 2-methoxynaphthalene-1-carbonyl chloride;2-Methoxy-1-naphthalenecarboxylic acid chloride
• CAS NO: 51439-58-8
• Molecular Formula: C₁₂H₉ClO₂
• Molecular Weight: 220.65166
• EINECS: 257-205-5
• Mol File: 51439-58-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 365.2°Cat760mmHg
• Flash Point: 134.7°C
• Appearance: /
• Density: 1.268g/cm³
• Vapor Pressure: 1.6E-05mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 2-methoxynaphthalene-1-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxynaphthalene-1-carbonyl chloride(51439-58-8)
• EPA Substance Registry System: 2-methoxynaphthalene-1-carbonyl chloride(51439-58-8)

Safety Data

• Hazardous Substances Data: 51439-58-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9ClO2/c1-15-10-7-6-8-4-2-3-5-9(8)11(10)12(13)14/h2-7H,1H3

Upstream product

• 947-62-6 2-methoxy-1-naphthoic acid 
• 883-21-6 1-methoxy-2-naphthoic acid 
• 5392-12-1 2-methoxy-1-naphthaldehyde 
• 13343-92-5 methyl ester of 2-methoxy-1-naphthalenecarboxylic acid 
• 3401-47-6 1-bromo-2-methoxynaphthalene 

Downstream Products

• 106542-96-5 phenyl 2-methoxy-1-naphthoate 
• 64506-84-9 β-{4-[2-(2-methoxy-naphthalene-1-carboxamido)-ethyl]-phenyl}-propionic acid 
• 824960-76-1 (2-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone 
• 818375-08-5 2-methoxy-1-naphthyl (2-acetamido-4,6-dimethoxy)phenyl ketone 
• 610794-07-5 2-methoxy-naphthalene-1-carboxylic acid benzyl-indan-2-yl-amide 
• 947-62-6 2-methoxy-1-naphthoic acid 
• 137869-22-8 2-phenyl-1-naphthaldehyde 
• 137869-15-9 2-(2-phenyl-1-naphthyl)oxazoline 
• 137869-18-2 2-<2-(O-methylephedrinyl)-1-naphthyl>oxazoline 
• 113056-73-8 2-p-tolyl-[1]naphthoic acid phenyl ester 
• 102595-97-1 2-phenyl-[1]naphthoic acid phenyl ester 
• 113056-97-6 2-o-tolyl-[1]naphthoic acid phenyl ester 
• 102664-91-5 2-benzyl-[1]naphthoic acid phenyl ester 
• 1415046-41-1 2-methoxy-6-(4-methoxyphenyl)-N,N-dimethyl-1-naphthamide 

Relevant articles and documents

Diastereoselective photocycloaddition using memory effect of molecular chirality controlled by crystallization

Naphthamides derived from L-proline, which exist as a mixture of several diastereomers in solution, converged to single diastereomer by crystallization, and the conformational transformation was controlled after the crystals were dissolved in the solvent at low temperature, where the frozen conformation was retained long enough for subsequent asymmetric reaction. The Royal Society of Chemistry.

Palladium-catalyzed C–P bond activation of aroyl phosphine oxides without the adjacent “anchoring atom”

A novel palladium-catalyzed decarbonylation of aroyl phosphine oxides to prepare phosphine oxides from carboxylic acids is developed. Without the adjacent “anchoring atom”, the challenging C–P bond activation is achieved in high selectivity. The disclosure of this reaction provides a new example of C–P bond activation and helps to extend the understanding of the property of C–P bond.

Synthesis, antitumor activity, and mechanism of action of benzo[a]pyrano[3,2-h]acridin-7-one analogues of acronycine

Twenty-two derivatives belonging to the cis-1,2-diacyloxy-6-methoxy-3,3,14- trimethyl-1,2,3,14-tetrahydro-7H-benzo[a]pyrano[3,2-h]acridin-7-one series were synthesized in nine steps starting from 3,5-dimethoxy-acetanilide (5) and 2-methoxy-1-naphthalenecarboxylic acid (7). Most of them exhibited submicromolar cytotoxicity when tested against murine leukemia (L1210) and human epidermoid carcinoma (KB-3-1) cell lines. The cytotoxic activity correlated strongly with the ability of the compounds to form covalent adducts with purified DNA. Among the most active compounds, 25, with IC50 values of 0.7 and 0.15 μM against L1210 and KB-3-1, respectively, was selected for evaluation in vivo against Colon 38 adenocarcinoma implanted in mice. This compound was active at 3 mg/kg iv (day 12 and 24) with 3/7 tumor free mice by day 80.