14212-38-5

Basic information

• Product Name: bis[(4-chlorophenyl)methyl]amine
• Synonyms: bis[(4-chlorophenyl)methyl]amine;OTAVA-BB 1404259;4-Chloro-alpha-(4-chlorophenyl)benzenemethanamine;Benzenemethanamine, 4-chloro-α-(4-chlorophenyl)-
• CAS NO: 14212-38-5
• Molecular Formula: C₁₃H₁₁Cl₂N
• Molecular Weight: 266.17
• Mol File: 14212-38-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: bis[(4-chlorophenyl)methyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: bis[(4-chlorophenyl)methyl]amine(14212-38-5)
• EPA Substance Registry System: bis[(4-chlorophenyl)methyl]amine(14212-38-5)

Safety Data

• Hazardous Substances Data: 14212-38-5(Hazardous Substances Data)

Upstream product

• 1714-50-7 4,4'-dichlorobenzophenone oxime 
• 77287-34-4 formamide 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 127568-36-9 N-(bis(4-chlorophenyl)methyl)formamide 
• 90-97-1 4,4'-dichlorobenzophenone 
• 623-03-0 4-Cyanochlorobenzene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 103035-65-0 N,N'-bis-(4,4'-dichloro-benzhydryl)-thiourea 
• 19495-07-9 di-p-chlorobenzhydrylisothiocyanate 
• 1026361-55-6 (1S,3aS,3bS,9aR,9bS,11aS)-1-{[Bis-(4-chloro-phenyl)-methyl]-carbamoyl}-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridine-5-carboxylic acid tert-butyl ester 
• 144267-27-6 4,4-di-p-chlorophenylthiazolidine-2,5-dithione 
• 144267-32-3 1-hydroxy-4,4-di-p-chlorophenylimidazolidine-2,5-dithione 
• 144267-50-5 4,4-di-p-chlorophenyl-5-n-pentadecylthio-2,3-(4H)-dihydroimidazole-2-thione 
• 144267-37-8 4,4-di-p-chlorophenyl-1-palmitoyloxy-imidazolidine-2,5-dithione 
• 1101850-30-9 (S)-N-{(R)-2-[bis(p-chlorophenyl)methylamino]-2-phenylethyl}prolinol 
• 1350710-39-2 4-[(1R,3R,4R)-4-{[bis(4-chlorophenyl)methyl]carbamoyl}-3-(4-bromophenyl)cyclohexyl]morpholine 

Relevant articles and documents

Chiral Carboxylic Acid Enabled Achiral Rhodium(III)-Catalyzed Enantioselective C?H Functionalization

Reported is an achiral CpxRhIII/chiral carboxylic acid catalyzed asymmetric C?H alkylation of diarylmethanamines with a diazomalonate, followed by cyclization and decarboxylation to afford 1,4-dihydroisoquinolin-3(2H)-one. Secondary

METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE

The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.

A practical synthesis of para di- and mono-substituted benzhydrylamines from benzhydrol precursors

A series of para-substituted benzhydrylamines 6 were obtained by substitution of the corresponding benzhydrol precursors 1 with phenyl carbamate 2 under acidic conditions, followed by basic hydrolysis of the carbamate intermediates 3. One unsymmetrical intermediate 3i has been resolved by preparative chiral chromatography. Subsequent deprotection of the carbamate function led to the recovery of enantiomerically pure (+)- and (-)- 4-chlorobenzhydryl amines.