1427004-19-0 Usage
Description
DBCO-PEG4-NHS Ester is a click chemistry PEG reagent that contains an NHS ester, enabling it to react specifically and efficiently with primary amines, such as the side chain of lysine residues or aminosilane-coated surfaces, under neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG spacer arm enhances water solubility and provides a long, flexible connection that minimizes steric hindrance during ligation. DBCO is commonly utilized in copper-free Click Chemistry reactions, making it a versatile tool for various applications.
Uses
Used in Bioconjugation:
DBCO-PEG4-NHS Ester is used as a bioconjugation agent for the incorporation of the cyclooctyne moiety into amine-containing compounds or biomolecules. This enables the formation of stable triazole linkages with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst.
Used in Protein-Peptide Conjugates:
In the pharmaceutical industry, DBCO-PEG4-NHS Ester is used as a key component in the creation of protein-peptide conjugates, allowing for the efficient and specific attachment of peptides to proteins.
Used in Antibody-Enzyme or Antibody-Drug Conjugates:
In the field of antibody-drug conjugates (ADCs), DBCO-PEG4-NHS Ester is employed as a crucial element for the formation of antibody-enzyme or antibody-drug conjugates, enhancing the targeting and delivery of therapeutic agents to specific cells.
Used in Protein or Peptide-Oligonucleotide Conjugates:
DBCO-PEG4-NHS Ester is utilized as a conjugation agent in the development of protein or peptide-oligonucleotide conjugates, which have potential applications in gene therapy and other genetic research areas.
Used in Surface Modification:
In the materials science and engineering industry, DBCO-PEG4-NHS Ester is used for surface modification, allowing for the covalent attachment of various molecules to surfaces, such as in the creation of biocompatible coatings or the development of sensors.
Overall, DBCO-PEG4-NHS Ester is a versatile and valuable reagent in the fields of bioconjugation, pharmaceuticals, gene therapy, and materials science, thanks to its ability to facilitate copper-free Click Chemistry reactions and improve the efficiency of various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1427004-19-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,7,0,0 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1427004-19:
(9*1)+(8*4)+(7*2)+(6*7)+(5*0)+(4*0)+(3*4)+(2*1)+(1*9)=120
120 % 10 = 0
So 1427004-19-0 is a valid CAS Registry Number.
1427004-19-0Relevant articles and documents
STEROIDS AND ANTIBODY-CONJUGATES THEREOF
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Paragraph 00416, (2019/07/20)
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
STEROIDS AND PROTEIN-CONJUGATES THEREOF
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, (2018/05/27)
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
