23194-93-6

Basic information

• Product Name: (Z)-5,6-dihydrodibenzo[b,f]azocine
• Synonyms: (Z)-5,6-dihydrodibenzo[b,f]azocine
• CAS NO: 23194-93-6
• Molecular Formula: C₁₅H₁₃N
• Molecular Weight: 207.27042
• EINECS: -0
• Mol File: 23194-93-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 108-109 °C
• Boiling Point: 378.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.085±0.06 g/cm3(Predicted)
• PKA: 4.44±0.20(Predicted)
• CAS DataBase Reference: (Z)-5,6-dihydrodibenzo[b,f]azocine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5,6-dihydrodibenzo[b,f]azocine(23194-93-6)
• EPA Substance Registry System: (Z)-5,6-dihydrodibenzo[b,f]azocine(23194-93-6)

Safety Data

• Hazardous Substances Data: 23194-93-6(Hazardous Substances Data)

Usage

Description

(Z)-5,6-dihydrodibenzo[b,f]azocine is an organic compound that serves as a crucial intermediate in the synthesis of various chemical compounds, particularly strained cyclooctyne derivatives. Its unique molecular structure and properties make it a valuable component in the development of new materials and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
(Z)-5,6-dihydrodibenzo[b,f]azocine is used as an intermediate for the synthesis of strained cyclooctyne derivatives, which are important in the development of new drugs and pharmaceutical compounds. These derivatives have potential applications in various therapeutic areas due to their unique chemical properties and reactivity.
Used in Chemical Synthesis:
In the field of chemical synthesis, (Z)-5,6-dihydrodibenzo[b,f]azocine is used as a key building block for the creation of complex molecular structures. Its incorporation into these structures can lead to the development of novel materials with specific properties, such as improved stability, reactivity, or selectivity in various chemical reactions.
Used in Research and Development:
(Z)-5,6-dihydrodibenzo[b,f]azocine is also utilized in research and development settings, where it can be employed to study the properties and behavior of strained cyclooctyne derivatives. This knowledge can be applied to the design and synthesis of new compounds with potential applications in various industries, including pharmaceuticals, materials science, and chemical engineering.

Upstream product

• 1207355-24-5 tert-butyl {2-[(Z)-2-(2-formylphenyl)ethenyl]phenyl}carbamate 
• 23112-88-1 dibenzo[b,f]azocin-6(5H)-one 
• 1021-91-6 N-[tricyclo[9.4.0.0^3,8]pentadeca-1⁽¹¹⁾,3,5,7,9,12,14-heptaen-2-ylidene]hydroxylamine 
• 2222-33-5 dibenzosuberenon 
• 1451735-20-8 2-iodo-N-(2-vinylbenzyl)aniline 
• 615-43-0 2-iodophenylamine 
• 28272-96-0 2-vinylbenzaldehyde 
• 1040308-67-5 N-(2-bromobenzyl)-2-iodoaniline 
• 92988-08-4 trivinylboroxin 
• 25261-48-7 N-(o-bromophenyl)-o-bromobenzylamine 
• 95-51-2 o-chloroaniline 
• 356531-17-4 N-(2-bromobenzyl)-2-chloroaniline 
• 2554-06-5 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-cyclotetrasiloxane 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1255942-06-3 N-(3-aminopropionyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocine 
• 1255942-07-4 DBCO-4PEG-biotin 
• 1255942-12-1 N-boc protected ADIBO-PEG₄-amine 
• 1255942-08-5 DBCO-PEG₄-amine 
• 1337920-23-6 N-(3-trifluoroacetamidopropanoyl)-5,6-Dihydro-11,12-Didehydrodibenzo[b,f]azocine 
• 1341223-26-4 N-(6-(1-benzyl-1H-dibenzo[b,f][1,2,3]triazolo[4,5-d]azocin-8(9H)-yl)-6-oxohexyl)-4-[18F]fluorobenzamide 
• 1341223-27-5 32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid 
• 1341223-25-3 C₂₈H₂₅⁽¹⁸⁾FN₂O₂ 
• 1353016-71-3 4-{2-azatricyclo[10.4.0.0⁴'⁹]hexadeca-1⁽¹²⁾,4⁽⁹⁾,5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid 
• 1364319-93-6 C₂₇H₂₃FN₄O₃ 
• 1364319-94-7 methyl 4-(1-(4-fluorophenyl)-1H-dibenzo[b,f][1,2,3]triazolo[4,5-d]azocin-8(9H)-yl)-4-oxobutanoate 
• 1353016-74-6 C₂₇H₂₃⁽¹⁸⁾FN₄O₃ 
• 1451735-25-3 C₂₂H₁₄BrNO 
• 1451735-26-4 C₃₃H₃₇BrN₄O₂ 

Relevant articles and documents

Azepine- or Azocine-Embedded Hexabenzocoronene Derivatives as Nitrogen-Doped Saddle or Saddle-Helix Nanographenes

Two novel nitrogen-doped, hexa-peri-hexabenzocoronene (HBC)-based nanographenes (NGs) 1 and 2 bearing an azepine and an azocine at the fjord region, respectively, were synthesized and characterized. Notably, structure 1 was synthesized by Diels–Alder reac

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A two-step strategy to radiolabel choline phospholipids with99mTc in S180 cell membranes via strain-promoted cyclooctyne–azide cycloaddition reaction

As tumor markers, the radiolabeling of choline (Cho)-containing phospholipids in cellular membranes with99mTc is a challenge. The conventional strategy to combine the metallic radionuclide with Cho by large ligand damages the bioactivity of Cho, resulting in low tumor-to-nontumor ratios. Pretargeting strategy based on strain-promoted cyclooctyne–azide cycloaddition (SPAAC) reaction was applied to solve this general problem. Functional click synthons were synthesized as pretargeting components: azidoethyl-choline (AECho) serves as tumor marker and azadibenzocyclooctyne (ADIBO) conjugated to bis(2-pieolyl) amine (BPA) ligand (ADIBO-BPA) as99mTc(CO)3-labeling and azido-binding group. Both in vitro cell experiment and in vivo biodistribution experiment indicate that it is versatile to radiolabel Cho in cellular membranes via this two-step pretargeting strategy. We believe that this pretargeting strategy can indeed enhance the target-specificity and also reduce background signals to optimize imaging quality.