1431527-09-1Relevant articles and documents
One-pot synthesis of chalcone epoxides - A green chemistry strategy
Ngo, Dalyna,Kalala, Mbelu,Hogan, Victoria,Manchanayakage, Renuka
, p. 4496 - 4500 (2014)
Waste minimization is a very important aspect of an environmentally benign protocol. A one-pot consecutive process has been developed for chalcone epoxide synthesis that allows compounds to be prepared without having to isolate and purify the intermediates. The strategy utilizes consecutive Claisen Schmidt condensation and epoxidation reactions to prepare chalcone epoxides from substituted benzaldehydes and acetophenones in good yields.
Practical approach for preparation of unsymmetric benzils from β-ketoaldehydes
Ruan, Libo,Shi, Min,Li, Nian,Ding, Xu,Yang, Fan,Tang, Jie
supporting information, p. 733 - 735 (2014/03/21)
An efficient and practical method for the synthesis of unsymmetric benzils from readily available β-ketoaldehydes has been developed. Various unsymmetric 1,2-diaryldiketones bearing functional groups have been obtained in good to excellent yields under mild reaction conditions. A plausible mechanism was proposed, and α,α-dichloroketone was considered as the key intermediate. The generation of α,α-dichloroketones from β-ketoaldehydes may undergo the following steps: (1) oxidation by sodium hypochlorite, (2) decarboxylation, and (3) chlorination by Cl2 generated from sodium hypochlorite.
