16216-14-1

Basic information

• Product Name: 1-(2-methoxyphenyl)-2-phenylethane-1,2-dione
• Synonyms: 1-(2-methylphenyl)-2-phenyl-1,2-ethanedione; 1-(2'-methylphenyl)-2-phenylethanedione; 1-phenyl-2-(o-tolyl)ethane-1,2-dione
• CAS NO: 16216-14-1
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.255
• Mol File: 16216-14-1.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 1-(2-methoxyphenyl)-2-phenylethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxyphenyl)-2-phenylethane-1,2-dione(16216-14-1)
• EPA Substance Registry System: 1-(2-methoxyphenyl)-2-phenylethane-1,2-dione(16216-14-1)

Safety Data

• Hazardous Substances Data: 16216-14-1(Hazardous Substances Data)

Usage

Type of compound

Synthetic estrogen

Purpose

Hormone replacement therapy for menopausal women

Action

Mimics the action of the hormone estrogen in the body

Uses

Alleviates symptoms such as hot flashes, vaginal dryness, and mood swings

Available forms

Tablets and creams

Administration

Typically taken orally

Precaution

Use under the guidance of a healthcare professional

Considerations

Be aware of potential side effects and contraindications

Upstream product

• 16216-13-0 2-phenyl-1-o-tolylethanone 
• 93-58-3 benzoic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 6699-93-0 (2-methylphenyl)lithium 
• 5033-67-0 2-(2-methylphenyl)-1-phenyl-1-ethanone 
• 932-31-0 ortho-tolylmagnesium bromide 
• 103-80-0 phenylacetyl chloride 
• 10166-09-3 (o-tolyl)acetyl chloride 
• 71-43-2 benzene 
• 14309-60-5 1-phenylethynyltoluene 
• 61001-54-5 2-methyldibenzoylmethane 
• 1398122-53-6 C₁₉H₂₀O₄ 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 14683-79-5 salicylaldoxime 

Downstream Products

• 102477-86-1 2-hydroxy-2,2-diphenyl-1-o-tolyl-ethanone 
• 5448-09-9 2-methylbenzilic acid 
• 111681-86-8 (S)-2-hydroxy-1-phenyl-2-(o-tolyl)ethan-1-one 
• 111681-86-8 2-hydroxy-2-(2-methylphenyl)-1-phenylethanone 
• 110247-81-9 1,1-diphenyl-2-o-tolylethane-1,2-diol 
• 1452219-68-9 2-hydroxy-2-(4-methoxyphenyl)-2-phenyl-1-(o-tolyl)ethanone 
• 1452219-70-3 2-(4-chlorophenyl)-2-hydroxy-2-phenyl-1-(o-tolyl)ethanone 
• 1452219-71-4 2-hydroxy-2-(naphthalen-1-yl)-2-phenyl-1-(o-tolyl)ethanone 
• 1452219-72-5 2-hydroxy-2-(naphthalen-2-yl)-2-phenyl-1-(o-tolyl)ethanone 
• 1146729-41-0 C₁₅H₁₆O₂ 
• 1580052-34-1 C₁₅H₁₆O₂ 

Relevant articles and documents

Synthesis of 1,2-diketones by mercury-catalyzed alkyne oxidation

The first mercury-catalyzed synthesis of 1,2-diketones by alkyne oxidation has been developed. This inexpensive method extends the potential of mercury catalysis and allows the rapid construction of various 1,2-diketones and α-carbonyl amides in good yields with high functional group tolerance.

Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi3complex with a macrocyclic tris(salen)-ligand

A hetero-tetranuclear CeNi3 complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce-O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.

Rhodium-Catalyzed Aerobic Decomposition of 1,3-Diaryl-2-diazo-1,3-diketones: Mechanistic Investigation and Application to the Synthesis of Benzils

The conversion of 1,3-diaryl-2-diazo-1,3-diketones to 1,2-daryl-1,2-diketones (benzils) is reported based on a rhodium(II)-catalyzed aerobic decomposition process. The reaction occurs at ambient temperatures and can be catalyzed by a few dirhodium carboxylates (5 mol %) under a balloon pressure of oxygen. Moreover, an oxygen atom from the O2 reagent is shown to be incorporated into the product, and this is accompanied by the extrusion of a carbonyl unit from the starting materials. Mechanistically, it is proposed that the decomposition may proceed via the interaction of a ketene intermediate resulting from a Wolff rearrangement of the carbenoid, with a rhodium peroxide or peroxy radical species generated upon the activation of molecular oxygen. The proposed mechanism has been supported by the results from a set of controlled experiments. By using this newly developed strategy, a large array of benzil derivatives as well as 9,10-phenanthrenequinone were synthesized from the corresponding diazo substrates in varying yields. On the other hand, the method did not allow the generation of benzocyclobutene-1,2-dione from 2-diazo-1,3-indandione because of the difficulty of inducing the initial rearrangement.