143669-41-4

Basic information

• Product Name: (1,4-Dioxan-2-yl)Methanol
• CAS NO: 143669-41-4
• Molecular Formula: C5H10O3
• Molecular Weight: 118.1311
• Mol File: 143669-41-4.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1,4-Dioxan-2-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1,4-Dioxan-2-yl)Methanol(143669-41-4)
• EPA Substance Registry System: (1,4-Dioxan-2-yl)Methanol(143669-41-4)

Safety Data

• Hazardous Substances Data: 143669-41-4(Hazardous Substances Data)

Usage

Description

(1,4-dioxan-2-yl)methanol, with the molecular formula C5H10O3, is a clear, colorless liquid characterized by a mild, slightly sweet odor. This chemical compound is known for its versatile applications across different industries.

Uses

Used in Industrial Applications:
(1,4-dioxan-2-yl)methanol is used as a solvent for various industrial processes, serving as a cleaner for electronic components and aiding in the dissolution of cellulose acetate.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (1,4-dioxan-2-yl)methanol is utilized in the production of various medications, playing a crucial role in the synthesis and formulation of drugs.
Used in Agricultural Chemicals:
(1,4-dioxan-2-yl)methanol also finds its application in the agricultural sector, where it is employed in the development of agricultural chemicals, contributing to crop protection and enhancement.
However, due to its hazardous nature, (1,4-dioxan-2-yl)methanol is regulated and requires careful handling. It has the potential to cause skin and eye irritation, and it can form explosive peroxides if exposed to air or light. Therefore, it is essential to follow proper safety protocols when working with this chemical compound.

Upstream product

• 5412-14-6 3-(β-Chloroethoxy)-1,2-epoxypropane 
• 99777-55-6 ethyl 2-(1,4-dioxan-2-ylmethoxy)crotonate 
• 143669-40-3 (+/-)-3,6,8-trioxabicyclo<3.2.1>octane 
• 16801-25-5 1-(2-hydroxyethoxy)-2,3-epoxypropane 
• 7664-93-9 sulfuric acid 
• 18371-74-9 1-chloro-3-(2-hydroxyethoxy)-2-propanol 
• 27905-76-6 2-(2-chloroethoxy)-3-chloropropan-2-ol 
• 87179-37-1 (+/-)-2-(bromomethyl)-4-(hydroxymethyl)-1,3-dioxalane 
• 92905-04-9 (+/-)-4-<(benzyloxy)methyl>-2-(bromomethyl)-1,3-dioxolane 
• 68391-40-2 acetoxymethyl-[1,4]dioxane 
• 35982-12-8 3-(2-chloroethoxy)-1,2-propanediol 
• 406913-87-9 (1S,5R)-3,6,8-trioxabicyclo[3.2.1]octane 
• 406913-91-5 Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester 
• 861852-08-6 (2R)-2-[(2-chloroethoxy)methyl]oxirane 

Downstream Products

• 21048-16-8 2-(chloromethyl)-1,4-dioxane 
• 934346-74-4 (R)-1,4-dioxane-2-carboxaldehyde 
• 406913-88-0 (R)-(-)-2-hydroxymethyl-1,4-dioxane 
• 406913-93-7 [(2S)-1,4-dioxan-2-yl]methanol 
• 917882-66-7 MK-2461 
• 917882-66-7 N-((2R)-1,4-dioxan-2-ylmethyl)-N-methyl-N’-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide 
• 1346262-49-4 (R)-2-{N-[((S)-1,4-dioxan-2-yl)methyl]-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide 
• 1337470-52-6 (S)-(1,4-dioxan-2-yl)methanamine 
• 1569298-20-9 C₁₀H₁₉NO₄ 
• 1512718-16-9 (1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate 
• 6249-69-0 1-(1,4-dioxan-2-yl)-N,N,N-trimethylmethanaminium iodide 
• 56217-56-2 1,4-dioxane-2-carbaldehyde 

Relevant articles and documents

Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein

Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to eval

Meso-Tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions

The synthesis of the low-molecular weight, meso-Tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-Type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base or zinc complex, it showed excellent solubility properties in organic and aqueous solvents, though free water-solubility was not achieved. The work expands on the availability of chiral porphyrins and neutral porphyrins with considerable solubility in aqueous solution.

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

Method for Producing Diarylpyridine Derivatives

The present invention relates to a novel method for producing diarylpyridine derivatives, and the object of the present invention is to provide a novel, industrially useful method. The present inventors developed a novel method for synthesizing pyridine r