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14433-76-2

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14433-76-2 Usage

Description

N,N-Dimethylcapramide, also known as N,N-Dimethyldecanamide, is an organic compound commonly utilized as an intermediate in the synthesis of various organic compounds. It is characterized by its amide functional group and two methyl groups attached to the nitrogen atom, which contribute to its unique chemical properties and applications.

Uses

Used in Pharmaceutical Industry:
N,N-Dimethylcapramide is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical industry, N,N-Dimethylcapramide is employed as an intermediate for the production of various agrochemicals. Its properties make it suitable for the synthesis of compounds used in the development of pesticides, herbicides, and other agricultural chemicals, helping to improve crop protection and yield.
Used in Veterinary Drug Industry:
N,N-Dimethylcapramide is also used as an intermediate in the veterinary drug industry. It plays a role in the synthesis of veterinary medications, contributing to the development of treatments for various animal health conditions and ensuring the well-being of livestock.
Used in Organic Synthesis:
As an intermediate for organic synthesis, N,N-Dimethylcapramide is utilized in the production of a wide range of organic compounds. Its unique structure and properties make it a valuable component in the synthesis of various chemicals used in different industries, including pharmaceuticals, agrochemicals, and others.

Check Digit Verification of cas no

The CAS Registry Mumber 14433-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,3 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14433-76:
(7*1)+(6*4)+(5*4)+(4*3)+(3*3)+(2*7)+(1*6)=92
92 % 10 = 2
So 14433-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H25NO/c1-4-5-6-7-8-9-10-11-12(14)13(2)3/h4-11H2,1-3H3

14433-76-2 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (L08731)  N,N-Dimethyldecanamide, 98%   

  • 14433-76-2

  • 5g

  • 854.0CNY

  • Detail
  • Alfa Aesar

  • (L08731)  N,N-Dimethyldecanamide, 98%   

  • 14433-76-2

  • 25g

  • 3550.0CNY

  • Detail

14433-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-Dimethyldecanamide

1.2 Other means of identification

Product number -
Other names N,N-dimethyldecanamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Agricultural chemicals (non-pesticidal),Intermediates,Surface active agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14433-76-2 SDS

14433-76-2Synthetic route

octanol
111-87-5

octanol

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Conditions
ConditionsYield
With C19H26ClIrNOP; potassium tert-butylate In toluene at 80℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;94%
With C29H55IrN3P2(1+)*Cl(1-); potassium tert-butylate In toluene at 120℃; for 15h; Schlenk technique; Inert atmosphere; Glovebox;76%
With C20H37ClN2OPRu; potassium tert-butylate In neat liquid at 140℃; for 24h; Inert atmosphere;36%
n-decanoyl chloride
112-13-0

n-decanoyl chloride

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Conditions
ConditionsYield
In benzene at 20℃;93%
In benzene 1.) 0 deg C, 1 h, 2.) r.t., 1 h;
N,N-dimethylammonium chloride
506-59-2

N,N-dimethylammonium chloride

n-decanoyl chloride
112-13-0

n-decanoyl chloride

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;76%
1-decanoic acid
334-48-5

1-decanoic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; copper(II) perchlorate hexahydrate at 100℃; for 6h;65%
S-phenyl decanethioate
51892-25-2

S-phenyl decanethioate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Conditions
ConditionsYield
With lithium perchlorate Electrochemical reaction;32 % Spectr.
1-decanoic acid
334-48-5

1-decanoic acid

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Conditions
ConditionsYield
Stage #1: 1-decanoic acid; dimethyl amine In water
Stage #2: In water at 240℃; under 15001.5 Torr; for 0.166667h; Product distribution / selectivity; Microvawe irradiation;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

1-dimethylaminodecyl-1,1-bisphosphonic acid
1196877-69-6

1-dimethylaminodecyl-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: N,N-dimethyldecanamide With phosphorous acid; phosphorus trichloride at 70℃; for 2h;
Stage #2: With water for 2h;
100%
Stage #1: N,N-dimethyldecanamide With phosphorous acid; phosphorus trichloride at 70℃; for 12h;
Stage #2: With water for 2h;
100%
Stage #1: N,N-dimethyldecanamide With phosphonic Acid; phosphorus trichloride at 70℃; for 2h;
Stage #2: With water at 100℃; for 3h;
100%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

N,N-dimethyldecylamine
1120-24-7

N,N-dimethyldecylamine

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; [Ru(1,1,1-tris(di(3,5-dimethoxyphenyl)phosphino-methyl)ethane)(trimethylenemethane)]; hydrogen In tetrahydrofuran at 160℃; under 75007.5 Torr; for 16h;97%
With 9-borabicyclo[3.3.1]nonane In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;88%
With n-pentyl methyl ketone; Dimethylphenylsilane; triethylamine; (μ3;η2;η3;η5-acenaphthylene)Ru3(CO)7 In various solvent(s) at 20℃; for 2h;79%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

1-((5-phenylpent-1-en-2-yl)oxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide

1-((5-phenylpent-1-en-2-yl)oxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide

2-oxo-5-phenylpentyl decanoate

2-oxo-5-phenylpentyl decanoate

Conditions
ConditionsYield
With water In toluene at 80℃; for 3h;85%
With water at 60℃; for 18h;85%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

C2F6NO4S2(1-)*C14H20NO(1+)

C2F6NO4S2(1-)*C14H20NO(1+)

3-cyclohexyl-2-oxopropyl decanoate

3-cyclohexyl-2-oxopropyl decanoate

Conditions
ConditionsYield
With water at 60℃; for 20h;85%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

N,N-dimethyldecane-1-amine hydrochloride
10237-16-8

N,N-dimethyldecane-1-amine hydrochloride

Conditions
ConditionsYield
Stage #1: N,N-dimethyldecanamide With bis(cyclopentadienyl)dihydrozirconium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane at 20℃; under 760.051 Torr; for 12h; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether Inert atmosphere;
83%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

dimethyl(phenyl)silyllithium
3839-31-4

dimethyl(phenyl)silyllithium

decanoyldimethyl(phenyl)silane
125828-13-9

decanoyldimethyl(phenyl)silane

Conditions
ConditionsYield
In tetrahydrofuran at -78℃; for 1.5h;82%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

lithium sodium dianion of methyl acetoacetate
64670-05-9

lithium sodium dianion of methyl acetoacetate

methyl 3,5-dioxotetradecanoate
100420-13-1

methyl 3,5-dioxotetradecanoate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -78 - 0℃; for 2h;74%
With boron trifluoride diethyl etherate; silica gel 1.)tetrahydrofuran, -78 --> 0 deg C, 2 h, 2.)room temp., overnight; Yield given. Multistep reaction;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

α-(dimethylamino)decyl cyanide
223801-43-2

α-(dimethylamino)decyl cyanide

Conditions
ConditionsYield
Stage #1: N,N-dimethyldecanamide With bis(triphenylphosphine)iridium(I) carbonyl chloride In toluene at 20℃; for 0.0833333h;
Stage #2: With 1,1,3,3-Tetramethyldisiloxane In toluene at 20℃; for 0.0833333h;
Stage #3: With trimethylsilyl cyanide In toluene at 20℃; for 0.5h;
72%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

aniline
62-53-3

aniline

decananilide
15473-32-2

decananilide

Conditions
ConditionsYield
With sodium t-butanolate In neat (no solvent) at 80℃; for 12h; Temperature; Inert atmosphere; Glovebox;72%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

benzylmagnesium chloride
6921-34-2

benzylmagnesium chloride

C19H33N

C19H33N

Conditions
ConditionsYield
Stage #1: N,N-dimethyldecanamide With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 20℃; for 0.333333h;
Stage #2: benzylmagnesium chloride at -78 - 20℃; for 4h;
58%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

1-Decanol
112-30-1

1-Decanol

Conditions
ConditionsYield
With ethanol; sodium In hexane; paraffin oil at 0℃; for 0.0833333h; Inert atmosphere;42%
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

2-octyl-3-oxo-dodecanoic acid dimethylamide
113860-70-1

2-octyl-3-oxo-dodecanoic acid dimethylamide

Conditions
ConditionsYield
With trichlorophosphate; benzene
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

aniline
62-53-3

aniline

N,N-dimethyl-N'-phenyl-decanamidine
110357-22-7

N,N-dimethyl-N'-phenyl-decanamidine

Conditions
ConditionsYield
With trichlorophosphate; benzene
pyrrole
109-97-7

pyrrole

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

1-(1H-pyrrol-2-yl)decan-1-one
89789-55-9

1-(1H-pyrrol-2-yl)decan-1-one

Conditions
ConditionsYield
With sodium hydroxide; water; trichlorophosphate 1) benzene, 18 h, 20 deg C, 2) 1 h, 20 deg C; Yield given. Multistep reaction;
1-Heptyne
628-71-7

1-Heptyne

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

Heptadec-6-yn-8-one
84907-65-3

Heptadec-6-yn-8-one

Conditions
ConditionsYield
Yield given. Multistep reaction;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

A

1-Decanol
112-30-1

1-Decanol

B

N,N-dimethyldecylamine
1120-24-7

N,N-dimethyldecylamine

Conditions
ConditionsYield
With sodium dimethylaminoborohydride In tetrahydrofuran at 66℃; for 55h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With ethanol; sodium In hexane at 0℃; for 0.333333h; Inert atmosphere; Overall yield = 73 %; Overall yield = 57.8 mg; chemoselective reaction;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

phenylacetylene
536-74-3

phenylacetylene

1-Phenyl-3-oxododec-1-yne
84907-66-4

1-Phenyl-3-oxododec-1-yne

Conditions
ConditionsYield
Yield given. Multistep reaction;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

((E)-Dec-1-enyl)-dimethyl-amine

((E)-Dec-1-enyl)-dimethyl-amine

Conditions
ConditionsYield
With titanium(IV) isopropylate; diphenylsilane at 20℃; Yield given;
2,4-dithiapentane
1618-26-4

2,4-dithiapentane

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

1,1-Bis-methylsulfanyl-undecan-2-one

1,1-Bis-methylsulfanyl-undecan-2-one

Conditions
ConditionsYield
With n-butyllithium 1) THF, hexane, -78 deg C, 2) THF, hexane, -78 deg C, 30 min; Yield given. Multistep reaction;
2,4-dithiapentane
1618-26-4

2,4-dithiapentane

N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

1,1,1-Tris-methylsulfanyl-undecan-2-one
171897-83-9

1,1,1-Tris-methylsulfanyl-undecan-2-one

Conditions
ConditionsYield
Yield given. Multistep reaction;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

caprinaldehyde
112-31-2

caprinaldehyde

Conditions
ConditionsYield
With bis-(1,2-dimethylpropyl)borane In tetrahydrofuran; dodecane at 25℃;85 % Chromat.
Multi-step reaction with 2 steps
1: Ti(O-i-Pr)4, Ph2SiH2 / 20 °C
2: 1 M aq. HCl / tetrahydrofuran / 20 °C
View Scheme
With C11H25AlNO4(1-)*Na(1+) In tetrahydrofuran; toluene at 0 - 20℃; for 0.5h;> 99 %Chromat.
With benzoic acid ethyl ester; copper diisobutyl-t-butoxyaluminum hydride In tetrahydrofuran at 20℃; for 12h; Reagent/catalyst; Inert atmosphere; chemoselective reaction;> 99 %Chromat.
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

(Z)-N,N,N',N'-Tetramethyl-icos-10-ene-10,11-diamine

(Z)-N,N,N',N'-Tetramethyl-icos-10-ene-10,11-diamine

Conditions
ConditionsYield
With dimethyl(phenyl)silyl lithium In tetrahydrofuran at -78 - -20℃; for 1h;
With dimethyl(phenyl)silyl lithium In tetrahydrofuran at -78 - -20℃; for 2h;
N,N-dimethyldecanamide
14433-76-2

N,N-dimethyldecanamide

11-(N,N-dimethyl)amino-10-eicosanone

11-(N,N-dimethyl)amino-10-eicosanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: PhMe2SiLi / tetrahydrofuran / 2 h / -78 - -20 °C
2: 243 mg / aq. HCl / 18 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: PhMe2SiLi / tetrahydrofuran / 1 h / -78 - -20 °C
2: H2O, HCl
View Scheme

14433-76-2Relevant articles and documents

-

Needles,H.L.,Whitfield,R.E.

, p. 989 - 990 (1966)

-

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

An, Duk Keun,Jaladi, Ashok Kumar,Kim, Hyun Tae,Yi, Jaeeun

supporting information, (2021/11/17)

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

A highly efficient catalytic α-alkylation of unactivated amides using primary alcohols

Yao, Wubing,Ma, Xiaochen,Guo, Le,Jia, Xiangqing,Hu, Aiguo,Huang, Zheng

supporting information, p. 2919 - 2921 (2016/06/13)

The α-alkylation of unactivated amides with alcohols is described. Using a NCP-type pincer Ir complex as the precatalyst and KOtBu as the base, the reactions of secondary or tertiary acetamides with benzyl or nonbenzyl primary alcohols occur at 80 °C, furnishing the alkylation products in good yields. This method represents a practical and green means of α-alkylation of amides in a relatively mild, efficient, and selective manner with low catalyst loadings (0.5 mol %).

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