1451070-67-9

Basic information

• Product Name: (20S)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne
• Synonyms: (20S)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne
• CAS NO: 1451070-67-9
• Molecular Weight: 769.428
• Mol File: 1451070-67-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (20S)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne(CAS DataBase Reference)
• NIST Chemistry Reference: (20S)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne(1451070-67-9)
• EPA Substance Registry System: (20S)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne(1451070-67-9)

Safety Data

• Hazardous Substances Data: 1451070-67-9(Hazardous Substances Data)

Upstream product

• 1451070-65-7 (3aR,4R,6R,7aR)-4,6-bis[(tert-butyldimethylsilyl)oxy]-5-methylene-3,3a,4,5,6,7-hexahydroindazole-7a-carboxylic acid methyl ester 
• 1227058-14-1 (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-4-methylene-cyclohex-1-enecarboxylic acid methyl ester 
• 213250-59-0 methyl (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy-4-methylenecyclohexanecarboxylate 
• 1428946-46-6 (3R,5R)-3,5-bis[(tert-butyldimethylsilyl)oxy]-2-methyl-4-methylene-cyclohex-1-enecarbaldehyde 
• 101906-39-2 Methyl (3R,4R,5R)-3,5-Bis<(tert-butyl)dimethylsilyloxy>-4-hydroxycyclohex-1-ene-1-carboxylate 
• 213250-68-1 1-(1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-one 
• 852380-64-4 (3R,5R)-5-[(tert-butyldimethylsilyl)oxy]-1,3-dihydroxy-4-methylene-cyclohexanecarboxylic acid methyl ester 
• 766529-88-8 (1R,3R,5R)-1-acetoxy-3-[(tert-butyldimethylsilyl)oxy]-6-oxa-bicyclo[3.2.1]octane-4,7-dione 
• 1431137-83-5 (20S)-25-[(triethylsilyl)oxy]-8-trifluoromethanesulfonyloxy-des-A,B-cholest-8-ene 

Downstream Products

• 1451070-71-5 (20S)-1α-[(tert-butyldimethylsilyl)oxy]-2-methylene-25-[(triethylsilyl)oxy]vitamin D₃ tert-butyl dimethylsilyl ether 
• 1428946-58-0 (20S)-1α,25-dihydroxy-2-methylene vitamin D₃ 
• 1428946-59-1 (5E)-(20S)-1α,25-dihydroxy-2-methylene vitamin D₃ 

Relevant articles and documents

Synthesis and Biological Activity of 2-Methylene Analogues of Calcitriol and Related Compounds

In an attempt to prepare Vitamin D analogues that are superagonists, (20R)- and (20S)-isomers of 1α-hydroxy-2-methyleneVitamin D3 and 1α,25-dihydroxy-2-methyleneVitamin D3 have been synthesized. To prepare the desired A-ring dienyne

2-methylene-vitamin D analogs and their uses

This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-1α,25 -dihydroxy-2-methylene-vitamin D3 as well as (5E)-(20S)-1α,25-dihydroxy-2 -methylene-vitamin D3 and (20R)-1α,25-dihydroxy-2-methylene-vitamin D