1477500-65-4Relevant articles and documents
5 the bit [...] modified purine ycin compound and its preparation and use
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, (2017/05/27)
The invention belongs to the field of chemical invention technology, and relates to a 5'-bit modified puromycin compound, and a preparation method and applications in drug screening thereof. The structure formula of the 5'-bit modified puromycin compound is described as following: R1 is protecting group Fmoc, Boc or Cbz; and R2 is protecting group Ac, Bz or Pv. The 5'-bit modified puromycin compound can be connected to the 5'-terminal of an oligonucleotide chain by solid phase phosphoramidite triester method, and is used for polypeptide medicine screening. The preparation method is simple, synthetic efficiency is high, and the 5'-bit modified puromycin compound is suitable for commercial synthesis.