151967-83-8

Basic information

• Product Name: [(S)-1-[(2S,3S,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-tetrahydro-furan-3-ylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• Synonyms: [(S)-1-[(2S,3S,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-tetrahydro-furan-3-ylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS NO: 151967-83-8
• Molecular Weight: 996.132
• Mol File: 151967-83-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(S)-1-[(2S,3S,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-tetrahydro-furan-3-ylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-[(2S,3S,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-tetrahydro-furan-3-ylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester(151967-83-8)
• EPA Substance Registry System: [(S)-1-[(2S,3S,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-tetrahydro-furan-3-ylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester(151967-83-8)

Safety Data

• Hazardous Substances Data: 151967-83-8(Hazardous Substances Data)

Upstream product

• 53-79-2 puromycin 
• 58-58-2 puromycin dihydrogen chloride 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 151967-82-7 [(S)-1-[(2S,3S,4R,5R)-5-(6-Dimethylamino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-ylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 

Downstream Products

• 1477500-63-2 C₆₀H₅₉N₇O₁₀ 
• 1477500-65-4 C₃₉H₄₁N₇O₈ 
• 1477500-67-6 C₄₈H₅₈N₉O₉P 

Relevant articles and documents

Facile synthesis of puromycin-tethered oligonucleotides at the 3'-end

A facile method for the synthesis of puromycin-tethered oligonucleotides at the 3'-end is described. The method utilizes a novel CPG support derived from commercially available puromycin. Puromycin-tethered DNA and RNA oligomers were synthesized using a puromycin-tethered CPG support by the usual protocol for automated DNA and RNA synthesis.

DNA display for drug discovery

A novel DNA display strategy, based on a new puromycin modifier, has been developed. The 5′-end puromycin-tethered oligonucleotide was synthesized to hybridize with mRNA, so that it could attack the nascent polypeptides during in vitro translation. The DNA-peptide fusion molecule can tolerate more harsh and stringent selection conditions, therefore, this DNA display may become a useful tool for in vitro display technologies for the selection of peptide drug candidates. The Royal Society of Chemistry 2013.