151967-82-7Relevant articles and documents
DNA display for drug discovery
Chen, Haodong,Chen, Gangyi,Du, Feng,Fu, Qingquan,Zhao, Yun,Tang, Zhuo
, p. 16251 - 16254 (2013)
A novel DNA display strategy, based on a new puromycin modifier, has been developed. The 5′-end puromycin-tethered oligonucleotide was synthesized to hybridize with mRNA, so that it could attack the nascent polypeptides during in vitro translation. The DNA-peptide fusion molecule can tolerate more harsh and stringent selection conditions, therefore, this DNA display may become a useful tool for in vitro display technologies for the selection of peptide drug candidates. The Royal Society of Chemistry 2013.
Facile synthesis of puromycin-tethered oligonucleotides at the 3'-end
Ikeda, Shuji,Saito, Isao,Sugiyama, Hiroshi
, p. 5975 - 5978 (2007/10/03)
A facile method for the synthesis of puromycin-tethered oligonucleotides at the 3'-end is described. The method utilizes a novel CPG support derived from commercially available puromycin. Puromycin-tethered DNA and RNA oligomers were synthesized using a puromycin-tethered CPG support by the usual protocol for automated DNA and RNA synthesis.