1486-47-1Relevant articles and documents
Polytopic carriers for platinum ions: From digalloyl depside to tannic acid
Fogagnolo, Marco,Bergamini, Paola,Marchesi, Elena,Marvelli, Lorenza,Gambari, Roberto,Lampronti, Ilaria
, p. 12227 - 12235 (2020)
A novel dinuclear platinum(ii) complex, namely [Pt2m-GG(Me2SO-S)4] (8, GG = deprotonated methyl digallate), was easily synthesized under solvent-free conditions by grinding a solid m/p digalloyl depside with the Pt precursor [PtCO3(Me2SO-S)2]. Similarly, platinum nuclei were introduced into the galloyl chains of tannic acid (TA). In particular, three complexes A, B and C were prepared by reacting TA as a polytopic ligand with an increasing amount of [PtCO3(Me2SO-S)2]. The antiproliferative activity of complexes 8, A, B and C together with the corresponding ligands GG and TA was tested in vitro and compared with that of cisplatin on two human tumor cell lines, A2780 (ovarian cisplatin-sensitive) and A2780cis (ovarian cisplatin-resistant), and one non-tumoral cell line, HaCat. The experiments focusing on their pro-apoptotic activity indicated that the antiproliferative activity of the most active Pt(II) complexes is associated with the induction of apoptosis. This journal is
Hydrolyzable tannins with the hexahydroxydiphenoyl unit and the m-depsidic link: HPLC-DAD-MS identification and model synthesis
Arapitsas, Panagiotis,Menichetti, Stefano,Vincieri, Franco F.,Romani, Annalisa
, p. 48 - 55 (2007)
This study was designed to develop efficient analytical tools for the difficult HPLC-DAD-MS identification of hydrolyzable tannins in natural tissue extracts. Throughout the study of the spectroscopic characteristics of properly synthesized stereodefined
Gallic esters of sucrose as efficient radical scavengers in lipid peroxidation
Dufour, Claire,Da Silva, Eric,Potier, Pierre,Queneau, Yves,Dangles, Olivier
, p. 3425 - 3430 (2002)
Three tests of increasing complexity were used to assess the antioxidant activity of five synthetic gallic esters of sucrose bearing 3, 6, 7, or 8 galloyl units. In addition, two of these compounds had 1 or 2 hydrocarbon (C10-C12) acyl chains. Reaction with the DPPH radical led to the evaluation of the number of radicals trapped per galloyl unit n (3-4), as well as the apparent second-order rate constant for H atom donation k (1200-1500/M/s). These results indicated similar contribution and reactivity of all the galloyl units. Inhibition of the AAPH-initiated peroxidation of linoleic acid in a micellar medium confirmed the additive contribution of the galloyl units, whereas the presence of the hydrocarbon acyl chains had no influence. These results suggest an inhibition of initiation at high antioxidant levels and an underlying prooxidant effect of the galloyl radicals at low concentrations. Finally, LDL peroxidation was inhibited in proportion to the number of galloyl units, in agreement with the preceding tests.
Total Synthesis of Macaranin B
Aoyama, Akio,Matsumoto, Shintaro,Wakamori, Shinnosuke,Yamada, Hidetoshi
, p. 1937 - 1944 (2021/09/13)
This study describes the total synthesis of macaranin B, a naturally occurring ellagitannin containing 1-O-galloyl and 3,6-O-macaranoyl groups in an axial-rich d-glucose. The key steps of the synthesis include an oxidative coupling reaction of galloyl gro
Asymmetric total synthesis of talienbisflavan A
Huang, Deng-Ming,Li, Hui-Jing,Wang, Jun-Hu,Wu, Yan-Chao
supporting information, p. 585 - 592 (2018/02/07)
The first asymmetric total syntheses of talienbisflavan A and bis-8,8′-epicatechinylmethane as well as a facile synthesis of bis-8,8′-catechinylmethane has been accomplished from readily available starting materials by using a newly developed direct regio