150-86-7 Usage
Description
Phytol, also known as trans-Phytol, is a diterpene alcohol derived from the degradation of chlorophyll. It is a colorless to yellow viscous liquid with a faint floral aroma and low strength odor. Phytol has been used in the synthesis of Vitamins E and K and is known for its sedative, anxiolytic, and antischistosomal properties.
Uses
Used in Pharmaceutical Industry:
PHYTOL is used as a reagent for the preparation of α-tocopherol analogs, which serve as mitochondrial antioxidants. This application is particularly relevant in the development of treatments for various diseases and conditions related to oxidative stress and mitochondrial dysfunction.
Used in Vitamin Synthesis:
PHYTOL is used as a key component in the preparation of vitamins E and K1. These vitamins play crucial roles in maintaining overall health, with vitamin E acting as an antioxidant and vitamin K being essential for blood clotting and bone metabolism.
Used in Aroma Industry:
PHYTOL is used as a fragrance ingredient due to its floral aroma. It can be incorporated into various products such as perfumes, lotions, and other personal care items to provide a pleasant scent.
Used in Metabolic Disorders Research:
PHYTOL is used in the study of metabolic disorders, particularly those involving the accumulation of phytanic acid. The conversion of phytol to phytanic acid is regulated via the activation of peroxisome proliferator-activated receptor α (PPARα), making it an important compound for understanding the underlying mechanisms of these disorders.
Used in Retinoid X Receptor Activation:
PHYTOL and its metabolites have been reported to activate retinoid X receptors (RXRs) and promote the activity of PPAR/RXR heterodimers. This application is significant in the field of molecular biology and pharmacology, as it can help in the development of new therapeutic strategies for various diseases.
Occurrence:
Phytol has been reported to be found in Herniaria incana lam oil (2.60%) and Witch hazel leaf oil (9.79%), indicating its natural presence in certain plant sources.
Safety Profile
Low toxicity by
ingestion and skin contact. A skin irritant.
When heated to decomposition it emits
acrid smoke and irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 150-86-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 150-86:
(5*1)+(4*5)+(3*0)+(2*8)+(1*6)=47
47 % 10 = 7
So 150-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H40O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h15,17-19,21H,6-14,16H2,1-5H3/b20-15+/t18-,19+/m0/s1
150-86-7Relevant articles and documents
van Rysselberghe et al.
, p. 809 (1947)
New 29-nor-cycloartanes with a 3,4-seco- and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis
Kashiwada, Yoshiki,Nishimura, Kazuya,Kurimoto, Shin-Ichiro,Takaishi, Yoshihisa
experimental part, p. 2790 - 2796 (2011/06/19)
Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29-nor-cycloartanes, sinocalycanchinensins G and H (7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities.
A convenient and asymmetric protocol for the synthesis of natural products containing chiral alkyl chains via Zr-catalyzed asymmetric carboalumination of alkenes. Synthesis of phytol and vitamins E and K.
Huo,Negishi
, p. 3253 - 3256 (2007/10/03)
[reaction: see text]. A convenient and asymmetric protocol for the synthesis of chiral oligoisoprenoids is described. Typically, a C14 vitamin E side chain 5 was synthesized in 47% yield over four steps. Isomeric purity of 5 was upgraded to >99% R at C-2 and 97% R at C-6 by the statistical formation of stereoisomeric p-phenylenebisurethanes and their diastereomeric separation. In addition, phytol and vitamin K were synthesized in 21% and 28% overall yields, respectively, over five steps from 1.