15118-68-0

Basic information

• Product Name: ethyl 2-methyl-4-(4-methoxyphenyl)-4-oxobutanoate
• Synonyms: ethyl 2-methyl-4-(4-methoxyphenyl)-4-oxobutanoate
• CAS NO: 15118-68-0
• Molecular Weight: 250.295
• Mol File: 15118-68-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: ethyl 2-methyl-4-(4-methoxyphenyl)-4-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-methyl-4-(4-methoxyphenyl)-4-oxobutanoate(15118-68-0)
• EPA Substance Registry System: ethyl 2-methyl-4-(4-methoxyphenyl)-4-oxobutanoate(15118-68-0)

Safety Data

• Hazardous Substances Data: 15118-68-0(Hazardous Substances Data)

Upstream product

• 7099-91-4 p-methoxybenzoylformic acid 
• 97-63-2 methyl methacrylate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 53927-01-8 N-(1-(4-methoxyphenyl)vinyl)piperidine 
• 535-11-5 Ethyl 2-bromopropionate 
• 637-69-4 4-Methoxystyrene 
• 4100-80-5 2-methylsuccinic anhydride 
• 100-66-3 methoxybenzene 
• 77902-90-0 rac-2-(Trifluormethylsulfonyloxy)propionsaeure-ethylester 
• 113777-08-5 1-Ethoxy-2-methyl-1-(trimethylsilyloxy)cyclopropan 
• 100-07-2 4-methoxy-benzoyl chloride 
• 14308-38-4 2,2-diethoxy-5-(4-methoxy-phenyl)-3-methyl-2,3-dihydro-furan 
• 5717-16-8 2-methyl-4-oxo-4-(4-methoxyphenyl)-butyric acid 

Downstream Products

• 1367306-80-6 C₁₆H₂₁ClO₄ 
• 66123-82-8 4-(4-hydroxy-phenyl)-2-methyl-4-oxo-butyric acid ethyl ester 
• 627877-81-0 carbonic acid 5-(4-methoxyphenyl)-3-methylfuran-2-yl ester phenyl ester 
• 5717-16-8 2-methyl-4-oxo-4-(4-methoxyphenyl)-butyric acid 

Relevant articles and documents

Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.

Visible light-induced intermolecular radical addition: Facile access to γ-ketoesters from alkyl-bromocarboxylates and enamines

A highly efficient addition of alkyl α-bromocarboxylates to enamines by visible light-induced photoredox catalysis is reported. Compared with traditional methods, the reaction described here provided an alternative route for the construction of valuable γ-ketoesters in generally good yields.

Enantioselective TADMAP-catalyzed carboxyl migration reactions for the synthesis of stereogenic quaternary carbon

The chiral, nucleophilic catalyst TADMAP [1, 3-(2,2,2-triphenyl-1- acetoxyethyl)-4-(dimethylamino)-pyridine] has been prepared from 3-lithio-4-(dimethylamino)pyridine (5) and triphenylacetaldehyde (3), followed by acylation and resolution. TADMAP catalyzes the carboxyl migration of oxazolyl, furanyl, and benzofuranyl enol carbonates with good to excellent levels of enantioselection. The oxazole reactions are especially efficient and are used to prepare chiral lactams (23) and lactones (30) containing a quaternary asymmetric carbon. TADMAP-catalyzed carboxyl migrations in the indole series are relatively slow and proceed with inconsistent enantioselectivity. Modeling studies (B3LYP/6-31G*) have been used in qualitative correlations of catalyst conformation, reactivity, and enantioselectivity.