1530777-90-2 Usage
Description
Tos-PEG7-CH2CO2t-butyl ester, also known as Tos-PEG7-CH2CO2tBu, is a PEG (polyethylene glycol) linker that features a t-butyl ester and a tosyl group. This molecule is designed to enhance solubility in aqueous media due to the hydrophilic PEG spacer. The t-butyl protected carboxyl group can be deprotected under acidic conditions, allowing for further chemical modifications or reactions. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions, making Tos-PEG7-CH2CO2t-butyl ester a versatile building block in various chemical and biological applications.
Uses
Used in Bioconjugation and Drug Synthesis:
Tos-PEG7-CH2CO2t-butyl ester is used as a versatile linker for bioconjugation and drug synthesis. The hydrophilic PEG spacer improves the solubility of the molecule in aqueous environments, which is crucial for biological applications. The t-butyl ester can be deprotected under acidic conditions, enabling the attachment of various functional groups or biomolecules, such as peptides, proteins, or small molecule drugs.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Tos-PEG7-CH2CO2t-butyl ester is used as a component in drug delivery systems. The PEG spacer enhances the solubility and stability of drug molecules, while the t-butyl ester and tosyl group provide opportunities for targeted drug release under specific conditions, such as in response to pH changes or enzymatic activity in the body.
Used in Chemical Synthesis:
Tos-PEG7-CH2CO2t-butyl ester is also used as a reagent in chemical synthesis, particularly in the preparation of PEGylated compounds. The tosyl group acts as a good leaving group for nucleophilic substitution reactions, allowing for the introduction of various functional groups or other molecules to the PEG chain, which can be used for a wide range of applications, including the development of new drugs, materials, or chemical sensors.
Used in Diagnostics and Imaging:
In the field of diagnostics and imaging, Tos-PEG7-CH2CO2t-butyl ester can be used as a component in the development of contrast agents or imaging probes. The PEG spacer can improve the biocompatibility and circulation time of these agents in the body, while the t-butyl ester and tosyl group can be used to attach specific targeting moieties or imaging labels, enhancing the specificity and sensitivity of the diagnostic or imaging process.
Check Digit Verification of cas no
The CAS Registry Mumber 1530777-90-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,0,7,7 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1530777-90:
(9*1)+(8*5)+(7*3)+(6*0)+(5*7)+(4*7)+(3*7)+(2*9)+(1*0)=172
172 % 10 = 2
So 1530777-90-2 is a valid CAS Registry Number.
1530777-90-2Relevant articles and documents
TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT
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, (2021/12/23)
The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.
Multimeric cyclic RGD peptides as potential tools for tumor targeting: Solid-phase peptide synthesis and chemoselective oxime ligation
Thumshirn, Georgette,Hersel, Ulrich,Goodman, Simon L.,Kessler, Horst
, p. 2717 - 2725 (2007/10/03)
The αvβ3 integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Targeting this receptor may provide information about the receptor status of the tumor and enable specific therapeutic planning. Solid-phase peptide synthesis of multimeric cyclo(-RGDfE-)-peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects. These peptides contain an aminooxy group for versatile chemoselective oxime ligation. Conjugation with para-trimethylstannylbenzaldehyde results in a precursor for radioiododestannylation, which would allow them to be used as potential tools for targeting and imaging αvβ3-expressing tumor cells. The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions.
