437655-96-4

Basic information

• Product Name: Fmoc-NH-PEG6-CH2COOH
• Synonyms: Fmoc-NH-PEG6-CH2COOH;1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azatetracosan-24-oic acid
• CAS NO: 437655-96-4
• Molecular Formula: C₂₉H₃₉NO₁₀
• Molecular Weight: 561.62066
• EINECS: -0
• Mol File: 437655-96-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Fmoc-NH-PEG6-CH2COOH(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-NH-PEG6-CH2COOH(437655-96-4)
• EPA Substance Registry System: Fmoc-NH-PEG6-CH2COOH(437655-96-4)

Safety Data

• Hazardous Substances Data: 437655-96-4(Hazardous Substances Data)

Usage

Description

Fmoc-NH-PEG6-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Upstream product

• 2615-15-8 pentaethylene glycol 
• 297162-50-6 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester 
• 297162-49-3 tert-butyl 20-azido-3,6,9,12,15,18-hexaoxaeicosanoate 
• 1530777-90-2 tert-butyl 20-(tosyloxy)-3,6,9,12,15,18-hexaoxicosanoate 
• 868594-44-9 20-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18-hexaoxaeicosan-1-ol 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 391684-36-9 2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid 

Downstream Products

• 600153-25-1 C₄₅H₇₂N₁₂O₁₉ 

Relevant articles and documents

MULTI-ARM TARGETING ANTI-CANCER CONJUGATE

A multi-branched dnig conjugate of formula (I) or a pharmaceutically acceptable salt thereof. In the formula, R is an organic center, POLY is a polymer, L is a multivalent linker, T is a targeting molecule, D is an active agent, and q is any integer between 3 and 8. The symbol “*” in L represents a junction point of the multivalent linker L and the targeting molecule T, “#” represents a junction point of the multivalent linker L and the active agent D, and “%” represents a junction point of the multivalent linker L and POLY. 1 is any integer between 2 and 20, and m and n are each an integer between 0 and 10. T is iRGD, cRGD, tLyp-1, Lyp-1, RPARPAR, Angiopep2, or GE11. D is a camptothecin drug.

Small and stable peptidic PEGylated quantum dots to target polyhistidine-tagged proteins with controlled stoichiometry

The use of the semiconductor quantum dots (QD) as biolabels for both ensemble and single-molecule tracking requires the development of simple and versatile methods to target individual proteins in a controlled manner, ideally in living cells. To address t

Multimeric cyclic RGD peptides as potential tools for tumor targeting: Solid-phase peptide synthesis and chemoselective oxime ligation

The αvβ3 integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Targeting this receptor may provide information about the receptor status of the tumor and enable specific therapeutic planning. Solid-phase peptide synthesis of multimeric cyclo(-RGDfE-)-peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects. These peptides contain an aminooxy group for versatile chemoselective oxime ligation. Conjugation with para-trimethylstannylbenzaldehyde results in a precursor for radioiododestannylation, which would allow them to be used as potential tools for targeting and imaging αvβ3-expressing tumor cells. The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions.