297162-50-6

Basic information

• Product Name: 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester
• Synonyms: 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester
• CAS NO: 297162-50-6
• Molecular Weight: 395.494
• Mol File: 297162-50-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester(297162-50-6)
• EPA Substance Registry System: 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester(297162-50-6)

Safety Data

• Hazardous Substances Data: 297162-50-6(Hazardous Substances Data)

Usage

Chemical compound

20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester
Commonly used in the synthesis and production of pharmaceuticals and biologically active molecules
Amino acid derivative
Fatty acid derivative
Tert-butyl ester form makes it more stable and easier to handle in laboratory conditions
Used as a building block in the synthesis of complex molecules
Versatile properties make it an important component in research and development processes
Particularly important in the pharmaceutical and biotechnology industries

Upstream product

• 297162-47-1 tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate 
• 185990-09-4 tert-butyl 1-phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-oate 
• 24342-68-5 1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol 
• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 1530777-90-2 tert-butyl 20-(tosyloxy)-3,6,9,12,15,18-hexaoxicosanoate 
• 352439-34-0 17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl methanesulfonate 
• 86770-69-6 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 2615-15-8 pentaethylene glycol 
• 297162-49-3 tert-butyl 20-azido-3,6,9,12,15,18-hexaoxaeicosanoate 

Downstream Products

• 600153-25-1 C₄₅H₇₂N₁₂O₁₉ 
• 437655-96-4 20-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18-hexaoxaeicosanoic acid 

Relevant articles and documents

TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

Small and stable peptidic PEGylated quantum dots to target polyhistidine-tagged proteins with controlled stoichiometry

The use of the semiconductor quantum dots (QD) as biolabels for both ensemble and single-molecule tracking requires the development of simple and versatile methods to target individual proteins in a controlled manner, ideally in living cells. To address t

Multimeric cyclic RGD peptides as potential tools for tumor targeting: Solid-phase peptide synthesis and chemoselective oxime ligation

The αvβ3 integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Targeting this receptor may provide information about the receptor status of the tumor and enable specific therapeutic planning. Solid-phase peptide synthesis of multimeric cyclo(-RGDfE-)-peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects. These peptides contain an aminooxy group for versatile chemoselective oxime ligation. Conjugation with para-trimethylstannylbenzaldehyde results in a precursor for radioiododestannylation, which would allow them to be used as potential tools for targeting and imaging αvβ3-expressing tumor cells. The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions.