153681-82-4

Basic information

• Product Name: 6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid
• Synonyms: 6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid
• CAS NO: 153681-82-4
• Molecular Formula: C₁₅H₁₁ClN₂O₂
• Molecular Weight: 286.71304
• Mol File: 153681-82-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 493.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.36±0.40(Predicted)
• CAS DataBase Reference: 6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid(153681-82-4)
• EPA Substance Registry System: 6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid(153681-82-4)

Safety Data

• Hazardous Substances Data: 153681-82-4(Hazardous Substances Data)

Usage

General Description

6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid is a chemical compound with a complex structure that includes a quinazoline ring, a chloro group, a phenyl group, and a carboxylic acid group. It is a heterocyclic compound with potential pharmaceutical applications, particularly in the field of medicinal chemistry. The chloro group and phenyl group provide unique chemical properties, while the carboxylic acid group offers potential for drug delivery and controlled release. 6-chloro-4-phenyl-1,2-dihydroquinazoline-2-carboxylic acid may be of interest for further study and development in the pharmaceutical industry.

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 5958-08-7 6-chloro-4-phenylquinazoline-2-carboxylic acid 
• 88190-77-6 6-chloro-3,4-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 4015-28-5 6-chloro-4-phenylquinazoline 
• 17954-62-0 6-chloro-3,4-dihydro-4-phenylquinazoline 
• 62705-47-9 methyl 6-chloro-4-phenylquinazoline-2-carboxylate 
• 1373887-32-1 N-sec-butyl-6-chloro-4-phenylquinazoline-2-carboxamide 
• 1373887-33-2 N-sec-butyl-6-chloro-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1373887-35-4 6-chloro-N-isopropyl-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1373887-36-5 6-chloro-N,N-dihexyl-4-phenylquinazoline-2-carboxamide 
• 1373887-37-6 (6-chloro-4-phenylquinazolin-2-yl)(pyrrolidin-1-yl)methanone 
• 1373887-38-7 (6-chloro-4-phenylquinazolin-2-yl)(piperidin-1-yl)methanone 
• 1581275-44-6 N-benzyl-6-chloro-N-ethyl-4-phenylquinazoline-2-carboxamide 
• 1581275-65-1 N-benzyl-6-chloro-4-phenylquinazoline-2-carboxamide 

Relevant articles and documents

Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors

Structure-activity relationships (SARs) within the 4-phenylquinazoline-2- carboxamide series of translocator protein (TSPO) ligands have been explored further by the synthesis and TSPO binding affinity evaluation of N-benzyl-N-ethyl/methyl derivatives var

Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives

Reaction of hydroxyglycine with 2-aminobenzophenones gives 1,2-dihydro-4-phenyl-quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3,4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows the carboxylate group at C(2) and the methyl group at N(1) to be in axial positions.